Psoriasis is a multifaceted and-due to its comorbidities-multi-system disease. This is reflected by the wide spectrum of therapeutic options. Recently, efforts have been made to define evidence-based therapeutic standards to provide orientation for dermatologists' treatment decisions. Costly innovative therapeutics as well as increased awareness of long-term safety issues has led to the definition of objective treatment goals. In this regard, patient-reported outcomes are highly relevant. Here, results of recent developments in the field of evidence-based, patient-centered, goal-oriented therapy of psoriasis are summarized.