UNIGE document Scientific Article
previous document  unige:29139  next document
add to browser collection

Apathy and Executive Dysfunction in Alzheimer Disease

Lekeu, Françoise
Quittre, Anne
Charnallet, Annik
Published in Alzheimer Disease and Associated Disorders. 2010, vol. 24, no. 2, p. 131-137
Abstract Apathy, defined as a reduction in voluntary goal-directed behaviours (GDB), is one of the most common behavioural symptoms encountered in Alzheimer's disease (AD). However, the processes underlying the different components of apathy are still unclear. The aim of this study was to explore a particularly important aspect of executive function in daily life: multitasking (assessed with the Modified Six Elements Task (MSET)), and its relationship with apathy in AD. 67 participants (37 AD patients matched with 30 control participants) were screened using the MSET. Simultaneously, a close relative of each patient was given the Apathy Inventory (AI), which assesses three distinct dimensions of apathy (lack of initiative, lack of interest, emotional blunting). AD patients presented significantly more multitasking deficits than control participants. In addition, regression analyses revealed that the number of rule breaks on the MSET (inability to perform several tasks in a predefined time observing a number of rules) was the best predictor of apathy, and especially of lack of initiative. These results suggest that the relation between lack of initiative and multitasking has a specific character and that mechanisms underlying multitasking constitute a key component of GDB.
Keywords ApathyAlzheimer's diseaseMultitaskingExecutive functions
Full text
Research group Unité de psychopathologie et neuropsychologie cognitive (UPNC)
(ISO format)
ESPOSITO, Fabienne et al. Apathy and Executive Dysfunction in Alzheimer Disease. In: Alzheimer Disease and Associated Disorders, 2010, vol. 24, n° 2, p. 131-137. doi: 10.1097/WAD.0b013e3181c9c168 https://archive-ouverte.unige.ch/unige:29139

524 hits



Deposited on : 2013-08-09

Export document
Format :
Citation style :