The UVR8 UV-B Photoreceptor: Perception, Signaling and Response

Tilbrook, Kimberley; Arongaus, Adriana Beatriz; Binkert, Melanie; Heijde, Marc; Yin, Ruohe; Ulm, Roman

doi:10.1199/tab.0164

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Title		The UVR8 UV-B Photoreceptor: Perception, Signaling and Response
Authors		Tilbrook, Kimberley Arongaus, Adriana Beatriz Binkert, Melanie Heijde, Marc Yin, Ruohe Ulm, Roman
Published in		Arabidopsis Book. 2013, vol. 11, p. e0164
Abstract		Ultraviolet-B radiation (UV-B) is an intrinsic part of sunlight that is accompanied by significant biological effects. Plants are able to perceive UV-B using the UV-B photoreceptor UVR8 which is linked to a specific molecular signaling pathway and leads to UV-B acclimation. Herein we review the biological process in plants from initial UV-B perception and signal transduction through to the known UV-B responses that promote survival in sunlight. The UVR8 UV-B photoreceptor exists as a homodimer that instantly monomerises upon UV-B absorption via specific intrinsic tryptophans which act as UV-B chromophores. The UVR8 monomer interacts with COP1, an E3 ubiquitin ligase, initiating a molecular signaling pathway that leads to gene expression changes. This signaling output leads to UVR8-dependent responses including UV-B-induced photomorphogenesis and the accumulation of UV-B-absorbing flavonols. Negative feedback regulation of the pathway is provided by the WD40-repeat proteins RUP1 and RUP2, which facilitate UVR8 redimerization, disrupting the UVR8-COP1 interaction. Despite rapid advancements in the field of recent years, further components of UVR8 UV-B signaling are constantly emerging, and the precise interplay of these and the established players UVR8, COP1, RUP1, RUP2 and HY5 needs to be defined. UVR8 UV-B signaling represents our further understanding of how plants are able to sense their light environment and adjust their growth accordingly.
Identifiers		DOI: 10.1199/tab.0164 PMID: 23864838
Full text		Article (Published version) (6.5 MB) - Free access
Structures		Faculté des sciences / Section de biologie / Département de botanique et biologie végétale
Citation (ISO format)		TILBROOK, Kimberley et al. The UVR8 UV-B Photoreceptor: Perception, Signaling and Response. In: Arabidopsis Book, 2013, vol. 11, p. e0164. doi: 10.1199/tab.0164 https://archive-ouverte.unige.ch/unige:29081