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Title

Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls

Authors
Haukvik, U K
Nesvåg, R
McNeil, T
Hartberg, C B
Jönsson, E G
Agartz, I
Published in Psychological Medicine. 2012, vol. 42, no. 6, p. 1329-37
Abstract The increased occurrence of obstetric complications (OCs) in patients with schizophrenia suggests that alterations in neurodevelopment may be of importance to the aetiology of the illness. Abnormal cortical folding may reflect subtle deviation from normal neurodevelopment during the foetal or neonatal period. In the present study, we hypothesized that OCs would be related to cortical folding abnormalities in schizophrenia patients corresponding to areas where patients with schizophrenia display altered cortical folding when compared with healthy controls.
Keywords AdultAlgorithmsAnimalsCase-Control StudiesFemaleFetal Development/physiologyFrontal Lobe/abnormalities/embryologyFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsMagnetic Resonance Imaging/methodsMaleMiddle AgedObstetric Labor Complications/epidemiology/pathologyPregnancyPrevalenceSchizophrenia/epidemiology/pathology
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PMID: 22029970
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Research group Laboratoire d'imagerie et de psychopathologie développementale (693)
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HAUKVIK, U K et al. Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls. In: Psychological Medicine, 2012, vol. 42, n° 6, p. 1329-37. https://archive-ouverte.unige.ch/unige:29067

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Deposited on : 2013-08-07

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