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Title

Jenseits der Immunpathogenese Insulinresistenz und „epidermale Dysfunktion“ / Beyond immunopathogenesis. Insulin resistance and "epidermal dysfunction"

Authors
Buerger, C
Published in Der Hautarzt. 2012, vol. 63, no. 3, p. 178-83
Abstract Insulin is a central player in the regulation of metabolic as well as non-metabolic cells: inefficient signal transduction (insulin resistance) not only represents the cornerstone in the pathogenesis of type 2 diabetes mellitus, but also drives atherosclerosis through inducing endothelial dysfunction. Last but not least epidermal homeostasis depends on insulin. We summarize the effects of insulin on proliferation and differentiation of human keratinocytes as well as the relevance of cytokine-induced insulin resistance for alterations in epidermal homeostasis characteristic for psoriasis. Kinases involved in both insulin- as well as cytokine-receptor signaling represent potential targets for innovative therapeutics. Such small molecules would primarily normalize "epidermal dysfunction", thus complementing the immunomodulatory strategies of today's biologics.
Keywords Cell Differentiation/immunologyCell ProliferationCytokines/bloodDiabetes Mellitus, Type 2/immunologyEndothelium, Vascular/immunologyEpidermis/immunologyHomeostasis/physiologyHumansInsulin/physiologyInsulin Receptor Substrate Proteins/physiologyInsulin Resistance/physiologyInterleukin-1beta/bloodKeratinocytes/immunologyProtein-Serine-Threonine Kinases/physiologyPsoriasis/drug therapy/immunologyReceptor, Insulin/physiologySignal Transduction/physiologyp38 Mitogen-Activated Protein Kinases/physiology
Identifiers
PMID: 22349906
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Article (Published version) (373 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Mécanismes des pathologies de l'inflammation cutanée (919)
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(ISO format)
BOEHNCKE, Wolf-Henning, BOEHNCKE, Sandra, BUERGER, C. Jenseits der Immunpathogenese Insulinresistenz und „epidermale Dysfunktion“ / Beyond immunopathogenesis. Insulin resistance and "epidermal dysfunction". In: Der Hautarzt, 2012, vol. 63, n° 3, p. 178-83. https://archive-ouverte.unige.ch/unige:29058

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Deposited on : 2013-08-07

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