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Title

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

Authors
Lacraz, Grégory
Giroix, Marie-Hélène
Kassis, Nadim
Coulaud, Josiane
Galinier, Anne
Noll, Christophe
Schmidlin, Fabien
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Published in PLOS ONE. 2009, vol. 4, no. 9, p. e6963
Abstract Inflammation followed by fibrosis is a component of islet dysfunction in both rodent and human type 2 diabetes. Because islet inflammation may originate from endothelial cells, we assessed the expression of selected genes involved in endothelial cell activation in islets from a spontaneous model of type 2 diabetes, the Goto-Kakizaki (GK) rat. We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene expression, islet vascularization and fibrosis after treatment with the interleukin-1 (IL-1) receptor antagonist (IL-1Ra).
Keywords AnimalsAntioxidants/metabolismDiabetes Mellitus, Experimental/metabolismDiabetes Mellitus, Type 2/metabolismEndothelial Cells/cytologyGene Expression RegulationInflammationInterleukin 1 Receptor Antagonist Protein/metabolismInterleukin-1/metabolismIslets of Langerhans/cytologyMaleModels, BiologicalOxidative StressRatsRats, Wistar
Identifiers
PMID: 19742300
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Article (Published version) (507 Kb) - public document Free access
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Research group Fonction de l'îlot de Langerhans (324)
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LACRAZ, Grégory et al. Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat. In: PLOS ONE, 2009, vol. 4, n° 9, p. e6963. https://archive-ouverte.unige.ch/unige:28881

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Deposited on : 2013-07-11

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