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Mitotic spindle (DIS)orientation and DISease: cause or consequence?

Published in The Journal of Cell Biology. 2012, vol. 199, no. 7, p. 1025-35
Abstract Correct alignment of the mitotic spindle during cell division is crucial for cell fate determination, tissue organization, and development. Mutations causing brain diseases and cancer in humans and mice have been associated with spindle orientation defects. These defects are thought to lead to an imbalance between symmetric and asymmetric divisions, causing reduced or excessive cell proliferation. However, most of these disease-linked genes encode proteins that carry out multiple cellular functions. Here, we discuss whether spindle orientation defects are the direct cause for these diseases, or just a correlative side effect.
Keywords AnimalsCell PolarityCell Transformation, Neoplastic/genetics/metabolismCentrosome/metabolism/pathologyHumansMitosisMitotic Spindle Apparatus/genetics/metabolism/pathologyNervous System Diseases/genetics/metabolism/pathologyNeural Stem Cells/metabolism/physiology
PMID: 23266953
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Article (Published version) (1.5 MB) - public document Free access
Research groups Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) (922)
La division asymétrique (847)
(ISO format)
NOATYNSKA, Anna, GOTTA, Monica, MERALDI, Patrick. Mitotic spindle (DIS)orientation and DISease: cause or consequence?. In: The Journal of Cell Biology, 2012, vol. 199, n° 7, p. 1025-35. doi: 10.1083/jcb.201209015 https://archive-ouverte.unige.ch/unige:28856

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Deposited on : 2013-07-09

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