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Title

Further evidence for amyloid deposition in clinical pancreatic islet grafts

Authors
Westermark, Gunilla T
Davalli, Alberto M
Secchi, Antonio
Folli, Franco
Kin, Tatsuya
Shapiro, A M James
Korsgren, Olle
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Published in Transplantation. 2012, vol. 93, no. 2, p. 219-23
Abstract The reasons for the long-term complete or partial loss of islet graft function are unknown, but there are obviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of islet amyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of β cells.
Keywords AdultDiabetes Mellitus, Type 1/surgeryFatal OutcomeFemaleHumansImmunohistochemistryIslet Amyloid Polypeptide/metabolismIslets of Langerhans/metabolism/pathologyIslets of Langerhans Transplantation/adverse effects/mortality/pathology/physiologyLiver/metabolism/pathologyMaleMiddle AgedProprotein Convertase 2/metabolismTissue Donors
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PMID: 22193043
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Research group Transplantation et hépatologie (905)
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WESTERMARK, Gunilla T et al. Further evidence for amyloid deposition in clinical pancreatic islet grafts. In: Transplantation, 2012, vol. 93, n° 2, p. 219-23. https://archive-ouverte.unige.ch/unige:28752

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Deposited on : 2013-06-28

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