Nonactivated versus thrombin-activated platelets on wound healing and fibroblast-to-myofibroblast differentiation in vivo and in vitro

Scherer-pietramaggiori, Sandra; Tobalem, Mickael; Vigato, Enrico; Heit, Yvonne; Modarressi Ghavami, Seyed Ali; Hinz, Boris; Pittet Cuenod, Brigitte Maud; Pietramaggiori, Giorgio

doi:10.1097/PRS.0b013e3182362010

Scientific article

English

Nonactivated versus thrombin-activated platelets on wound healing and fibroblast-to-myofibroblast differentiation in vivo and in vitro

ContributorsScherer-pietramaggiori, Sandra; Tobalem, Mickael; Vigato, Enrico; Heit, Yvonne; Modarressi Ghavami, Seyed Ali; Hinz, Boris; Pittet Cuenod, Brigitte Maud; Pietramaggiori, Giorgio

Published inPlastic and reconstructive surgery, vol. 129, no. 1, p. 46e-54e

Publication date2012

Abstract

Platelet preparations for tissue healing are usually preactivated before application to deliver concentrated growth factors. In this study, the authors investigated the differences between nonactivated and thrombin-activated platelets in wound healing.

Keywords

Animals
Cell Differentiation
Cell Movement/physiology
Diabetes Mellitus, Experimental/physiopathology
Fibroblasts/physiology
Immunohistochemistry
Male
Mice
Mice, Inbred C57BL
Myofibroblasts/physiology
Neovascularization, Physiologic
Platelet Activation/physiology
Platelet-Rich Plasma/physiology
Thrombin/metabolism
Tissue Therapy/methods
Wound Healing/physiology

Affiliation

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research group

Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)

Citation (ISO format)

SCHERER-PIETRAMAGGIORI, Sandra et al. Nonactivated versus thrombin-activated platelets on wound healing and fibroblast-to-myofibroblast differentiation in vivo and in vitro. In: Plastic and reconstructive surgery, 2012, vol. 129, n° 1, p. 46e–54e. doi: 10.1097/PRS.0b013e3182362010

Article (Published version)

Identifiers

PID : unige:28733
DOI : 10.1097/PRS.0b013e3182362010
PMID : 22186584

ISSN of the journal0032-1052

627views

3downloads

Creation05/30/2013 12:05:00 PM

First validation05/30/2013 12:05:00 PM

Update time03/14/2023 8:19:30 PM

Status update03/14/2023 8:19:30 PM

Last indexation10/18/2023 4:26:23 PM

Archive ouverte UNIGE

Nonactivated versus thrombin-activated platelets on wound healing and fibroblast-to-myofibroblast differentiation in vivo and in vitro

Platelet preparations for tissue healing are usually preactivated before application to deliver concentrated growth factors. In this study, the authors investigated the differences between nonactivated and thrombin-activated platelets in wound healing.

Technical informations