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The neural correlates of object-centered processing in reading: a lesion study of neglect dyslexia

Published in Neuropsychologia. 2012, vol. 50, no. 6, p. 1142-50
Abstract Neglect dyslexia--a peripheral reading disorder generally associated with left spatial neglect--is characterized by omissions or substitutions of the initial letters of words. Several observations suggest that neglect dyslexia errors are independent of viewer-centered coordinates; the disorder is therefore thought to reflect impairment at the level of object-centered representations. This hypothesis is indirectly supported by lesion studies connecting object-centered neglect errors with damage to posterior cortical regions lying in the ventral visual stream. Here, we performed a lesion-symptom mapping study of 40 patients with spatial neglect asked to read words presented at different positions relative to a viewer-centered coordinate frame. We found that the frequency of object-centered reading errors was constant across horizontal positions, whereas the frequency of entirely neglected words (reflecting a page-centered deficit) linearly increased from right to left. Damage to the intraparietal sulcus and the angular and middle temporal gyri was the best predictor of object-centered errors. We discuss these findings with reference to a role of the posterior parietal lobe in adapting the size of the attentional focus and biasing object representations elaborated in the ventral visual stream.
Keywords AgedAged, 80 and overAttention/physiologyBrain MappingCerebral Cortex/pathologyDyslexia/complications/pathologyFemaleFunctional Laterality/physiologyHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPerceptual Disorders/complications/pathologyPhotic StimulationReadingVocabulary
PMID: 21982696
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Article (Published version) (1.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Lésions cérébrales et attention spatiale (705)
Swiss National Science Foundation: 320030_134591
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PTAK, Radek, DI PIETRO PERALTA-BACHMAN, Marie, SCHNIDER, Armin. The neural correlates of object-centered processing in reading: a lesion study of neglect dyslexia. In: Neuropsychologia, 2012, vol. 50, n° 6, p. 1142-50. doi: 10.1016/j.neuropsychologia.2011.09.036 https://archive-ouverte.unige.ch/unige:28709

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Deposited on : 2013-06-26

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