en
Scientific article
English

The neural correlates of object-centered processing in reading: a lesion study of neglect dyslexia

Published inNeuropsychologia, vol. 50, no. 6, p. 1142-1150
Publication date2012
Abstract

Neglect dyslexia--a peripheral reading disorder generally associated with left spatial neglect--is characterized by omissions or substitutions of the initial letters of words. Several observations suggest that neglect dyslexia errors are independent of viewer-centered coordinates; the disorder is therefore thought to reflect impairment at the level of object-centered representations. This hypothesis is indirectly supported by lesion studies connecting object-centered neglect errors with damage to posterior cortical regions lying in the ventral visual stream. Here, we performed a lesion-symptom mapping study of 40 patients with spatial neglect asked to read words presented at different positions relative to a viewer-centered coordinate frame. We found that the frequency of object-centered reading errors was constant across horizontal positions, whereas the frequency of entirely neglected words (reflecting a page-centered deficit) linearly increased from right to left. Damage to the intraparietal sulcus and the angular and middle temporal gyri was the best predictor of object-centered errors. We discuss these findings with reference to a role of the posterior parietal lobe in adapting the size of the attentional focus and biasing object representations elaborated in the ventral visual stream.

Keywords
  • Aged
  • Aged, 80 and over
  • Attention/physiology
  • Brain Mapping
  • Cerebral Cortex/pathology
  • Dyslexia/complications/pathology
  • Female
  • Functional Laterality/physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Perceptual Disorders/complications/pathology
  • Photic Stimulation
  • Reading
  • Vocabulary
Citation (ISO format)
PTAK, Radek, DI PIETRO PERALTA-BACHMAN, Marie, SCHNIDER, Armin. The neural correlates of object-centered processing in reading: a lesion study of neglect dyslexia. In: Neuropsychologia, 2012, vol. 50, n° 6, p. 1142–1150. doi: 10.1016/j.neuropsychologia.2011.09.036
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ISSN of the journal0028-3932
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