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Scientific article
English

Creutzfeldt-Jakob disease revealed by a logopenic variant of primary progressive aphasia

Contributors

Martory, M D; Roth, S; Lövblad, Karl-Olof; Neumann, M; Lobrinus, Johannes Alexander; Assal, Frédéric

Published in

European neurology, vol. 67, no. 6, p. 360-362

Publication date

2012

Abstract

Logopenic aphasia, mainly characterized by word anomia, sentence and phrase comprehension difficulties secondary to phonological loop deficits but relatively preserved single word comprehension and no agrammatism, is one of the 3 main variants of primary progressive aphasia (PPA). We describe the first case of PPA that fulfilled clinical criteria of logopenic aphasia but showed abnormal DWI hyperintensities that were predominant on the left hemisphere and compatible with Creutzfeldt-Jakob disease (CJD). After abnormally long isolated language deficits, the patient rapidly worsened and died. Autopsy performed 18 months after onset of language difficulties confirmed the diagnosis. We therefore advocate performing DWI sequences in any suspicion of PPA in order to rule out CJD.

Keywords

  • Aphasia, Primary Progressive/classification/diagnosis/etiology
  • Comprehension/physiology
  • Creutzfeldt-Jakob Syndrome/complications
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Functional Laterality
  • Humans
  • Language
  • Middle Aged
  • Neuropsychological Tests
  • Temporal Lobe/pathology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MARTORY, M D et al. Creutzfeldt-Jakob disease revealed by a logopenic variant of primary progressive aphasia. In: European neurology, 2012, vol. 67, n° 6, p. 360–362. doi: 10.1159/000336796

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Article (Published version)

Identifiers

Journal ISSN

0014-3022
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