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Title

Mechanisms of xenogeneic baboon platelet aggregation and phagocytosis by porcine liver sinusoidal endothelial cells

Authors
Peng, Qiang
Yeh, Heidi
Wei, Lingling
Enjyoj, Keiichi
Machaidze, Zurab
Csizmad, Eva
Schuetz, Christian
Lee, Kang Mi
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Published in PLOS ONE. 2012, vol. 7, no. 10, p. e47273
Abstract Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. Histological examination of xenotransplanted livers has shown baboon platelet activation, phagocytosis and sequestration within the sinusoids. In order to study the mechanisms of platelet consumption in liver xenotransplantation, we have developed an in vitro system to examine the interaction between pig endothelial cells with baboon platelets and to thereby identify molecular mechanisms and therapies.
Keywords AnimalsAurintricarboxylic Acid/administration & dosageEndothelial Cells/cytology/metabolismHepatocytes/immunology/metabolismLiver Transplantation/adverse effectsMacrophage-1 Antigen/genetics/metabolismPapio/immunology/physiologyPeptides/administration & dosagePhagocytosis/genetics/immunologyPlatelet Aggregation/genetics/immunologyPlatelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitorsSwine/genetics/immunologyTransplantation, Heterologous/adverse effects/immunologyVon Willebrand Factor/antagonists & inhibitors/metabolism
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PMID: 23118867
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Article (Published version) (489 Kb) - public document Free access
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Research group Cultures cellulaires et transplantations (519)
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PENG, Qiang et al. Mechanisms of xenogeneic baboon platelet aggregation and phagocytosis by porcine liver sinusoidal endothelial cells. In: PLOS ONE, 2012, vol. 7, n° 10, p. e47273. https://archive-ouverte.unige.ch/unige:28647

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Deposited on : 2013-06-18

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