Article (Published version) (205 Kb) - Limited access to UNIGE
From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD.
|Published in||Nephrology, Dialysis, Transplantation. 2012, vol. 27 Suppl 3, p. iii43-50|
|Abstract||Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.|
|Keywords||Acute Kidney Injury/physiopathology — Disease Progression — Epithelial-Mesenchymal Transition — Humans — Kidney Failure, Chronic/physiopathology|
|PRUNOTTO, Marco et al. From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD. In: Nephrology, Dialysis, Transplantation, 2012, vol. 27 Suppl 3, p. iii43-50. https://archive-ouverte.unige.ch/unige:28458|