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Title

From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD.

Authors
Budd, David C
Meier, Matthias
Formentini, Ivan
Hartmann, Guido
Pomposiello, Silvia
Published in Nephrology, Dialysis, Transplantation. 2012, vol. 27 Suppl 3, p. iii43-50
Abstract Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.
Keywords Acute Kidney Injury/physiopathologyDisease ProgressionEpithelial-Mesenchymal TransitionHumansKidney Failure, Chronic/physiopathology
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PMID: 22785113
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PRUNOTTO, Marco et al. From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD. In: Nephrology, Dialysis, Transplantation, 2012, vol. 27 Suppl 3, p. iii43-50. https://archive-ouverte.unige.ch/unige:28458

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Deposited on : 2013-06-10

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