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Title

From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD.
Authors
Prunotto, Marco
Budd, David C
Meier, Matthias
Formentini, Ivan
Hartmann, Guido
Pomposiello, Silvia
Moll, Solange
Published in Nephrology, dialysis, transplantation. 2012, vol. 27 Suppl 3, p. iii43-50
Abstract Observational clinical studies link acute kidney injury to chronic kidney disease (CKD) progression. The pathophysiological mechanisms that underlie this process are currently unknown but recently published papers suggest that tubular epithelial cells and interstitial mesenchymal cells emerge as a single unit, and their integrity alteration as a whole might lead to renal fibrosis and CKD. The present article reviews the biological findings supporting the hypothesis of an altered epithelial/mesenchymal crosstalk in fibrosis development and progression toward CKD.
Keywords Acute Kidney Injury/physiopathology — Disease Progression — Epithelial-Mesenchymal Transition — Humans — Kidney Failure, Chronic/physiopathology
Identifiers
PMID: 22785113
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Article (Published version) (205 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Citation
(ISO format) 		PRUNOTTO, Marco et al. From acute injury to chronic disease: pathophysiological hypothesis of an epithelial/mesenchymal crosstalk alteration in CKD. In: Nephrology, dialysis, transplantation, 2012, vol. 27 Suppl 3, p. iii43-50. doi: 10.1093/ndt/gfs283 https://archive-ouverte.unige.ch/unige:28458

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Deposited on : 2013-06-10

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