UNIGE document Scientific Article - Review
previous document  unige:28456  next document
add to browser collection
Title

Epithelial-mesenchymal crosstalk alteration in kidney fibrosis

Authors
Budd, David C
Meier, Matthias
Formentini, Ivan
Hartmann, Guido
Pomposiello, Silvia
Published in The Journal of Pathology. 2012, vol. 228, no. 2, p. 131-47
Abstract The incidence of chronic kidney diseases (CKD) is constantly rising, reaching epidemic proportions in the western world and leading to an enormous threat, even to modern health-care systems, in industrialized countries. Therapies of CKD have greatly improved following the introduction of drugs targeting the renin-angiotensin system (RAAS) but even this refined pharmacological approach has failed to stop progression to end-stage renal disease (ESRD) in many individuals. In vitro historical data and recent new findings have suggested that progression of renal fibrosis might occur as a result of an altered tubulo-interstitial microenvironment and, more specifically, as a result of an altered epithelial-mesenchymal crosstalk. Here we the review biological findings that support the hypothesis of an altered cellular crosstalk in an injured local tubulo-interstitial microenvironment leading to renal disease progression. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keywords Cell Communication/physiologyCellular MicroenvironmentDisease ProgressionEpithelial Cells/pathologyEpithelial-Mesenchymal Transition/physiologyFeedback, Physiological/physiologyFibrosisHumansKidney/pathologyKidney Failure, Chronic/diagnosis/physiopathologyKidney Tubules/pathologyMesoderm/pathologyRenin-Angiotensin System/physiology
Identifiers
PMID: 22570261
Full text
Article (Published version) (2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Analyse protéomique et Analyse génomique des maladies rénales (659)
Citation
(ISO format)
PRUNOTTO, Marco et al. Epithelial-mesenchymal crosstalk alteration in kidney fibrosis. In: The Journal of Pathology, 2012, vol. 228, n° 2, p. 131-47. https://archive-ouverte.unige.ch/unige:28456

237 hits

0 download

Update

Deposited on : 2013-06-10

Export document
Format :
Citation style :