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Epithelial-mesenchymal crosstalk alteration in kidney fibrosis

Budd, David C
Meier, Matthias
Formentini, Ivan
Hartmann, Guido
Pomposiello, Silvia
Published in Journal of pathology. 2012, vol. 228, no. 2, p. 131-47
Abstract The incidence of chronic kidney diseases (CKD) is constantly rising, reaching epidemic proportions in the western world and leading to an enormous threat, even to modern health-care systems, in industrialized countries. Therapies of CKD have greatly improved following the introduction of drugs targeting the renin-angiotensin system (RAAS) but even this refined pharmacological approach has failed to stop progression to end-stage renal disease (ESRD) in many individuals. In vitro historical data and recent new findings have suggested that progression of renal fibrosis might occur as a result of an altered tubulo-interstitial microenvironment and, more specifically, as a result of an altered epithelial-mesenchymal crosstalk. Here we the review biological findings that support the hypothesis of an altered cellular crosstalk in an injured local tubulo-interstitial microenvironment leading to renal disease progression. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keywords Cell Communication/physiologyCellular MicroenvironmentDisease ProgressionEpithelial Cells/pathologyEpithelial-Mesenchymal Transition/physiologyFeedback, Physiological/physiologyFibrosisHumansKidney/pathologyKidney Failure, Chronic/diagnosis/physiopathologyKidney Tubules/pathologyMesoderm/pathologyRenin-Angiotensin System/physiology
PMID: 22570261
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Research group Analyse protéomique et Analyse génomique des maladies rénales (659)
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PRUNOTTO, Marco et al. Epithelial-mesenchymal crosstalk alteration in kidney fibrosis. In: Journal of pathology, 2012, vol. 228, n° 2, p. 131-47. doi: 10.1002/path.4049 https://archive-ouverte.unige.ch/unige:28456

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Deposited on : 2013-06-10

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