Article (Published version) (2.9 MB) - Free access
Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?
|Published in||Oxidative medicine and cellular longevity. 2012, vol. 2012, p. 740849|
|Abstract||In pancreatic β cells, mitochondrial metabolism translates glucose sensing into signals regulating insulin secretion. Chronic exposure of β cells to excessive nutrients, namely, glucolipotoxicity, impairs β-cell function. This is associated with elevated ROS production from overstimulated mitochondria. Mitochondria are not only the major source of cellular ROS, they are also the primary target of ROS attacks. The mitochondrial uncoupling protein UCP2, even though its uncoupling properties are debated, has been associated with protective functions against ROS toxicity. Hormesis, an adaptive response to cellular stresses, might contribute to the protection against β-cell death, possibly limiting the development of type 2 diabetes. Mitochondrial hormesis, or mitohormesis, is a defense mechanism observed in ROS-induced stress-responses by mitochondria. In β cells, mitochondrial damages induced by sublethal exogenous H(2)O(2) can induce secondary repair and defense mechanisms. In this context, UCP2 is a marker of mitohormesis, being upregulated following stress conditions. When overexpressed in nonstressed naïve cells, UCP2 confers resistance to oxidative stress. Whether treatment with mitohormetic inducers is sufficient to restore or ameliorate secretory function of β cells remains to be determined.|
|Keywords||Animals — Diabetes Mellitus, Type 2/metabolism/pathology — Glucose/metabolism — Hormesis — Humans — Insulin/metabolism/secretion — Insulin-Secreting Cells/cytology/metabolism/secretion — Ion Channels/metabolism — Mitochondria/metabolism — Mitochondrial Proteins/metabolism — Oxidative Stress — Reactive Oxygen Species/metabolism|
|Research group||Mitochondries et sécrétion d'insuline (671)|
|Project||FNS: 310030B_135704 / 1|
|LI, Ning, STOJANOVSKI, Suzana, MAECHLER, Pierre. Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?. In: Oxidative Medicine and Cellular Longevity, 2012, vol. 2012, p. 740849. https://archive-ouverte.unige.ch/unige:28230|