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Scientific article
English

Nucleosides and acyclonucleosides bearing a N-hydroxyureido group

Contributors

Tronchet, Jean Marcel Julien; Zsely Schaffter, Martina Maria; Iznaden, Mohammed; Barbalat, Françoise; Geoffroy, Michel; Bernardinelli, Gérald Hugues

Published in

Carbohydrate letters, vol. 2, no. 12, p. 101-108

Publication date

1996

Abstract

Hydroxyurea (HU), a ribonucleotide reductase inhibitor has been used in the treatment of some malignant and viral diseases and seems now to be promising, in association with 2,3dideoxynucleosides, for the management of AIDS. In an attempt to increase the specificity of action of this radical scavenger, or at least, to study the topological aspects of its reactivity, we introduced the N-hydroxyureido group into nucleosides by using Mitsunobu reaction or by reacting a nucleoside nitrogen nucleophile with a carbonyl electrophile. From the currently available antiviral testing results, concerning the nucleoside analogues it appears that the most noticable activity exert against Varicella Zoster virus (VZV). One acyclonucleoside derivative was found to be very active against the virus HIV-1, its therapeutic index is better than 100.000. We prepared peptid-like dinucleotide analogues33,36 also in which the internucleosidic bridge consists of a spacer of approximately the same length as in the natural compounds. These compounds could be tested as inhibitors of nucleotide-protein interactions, we supposed that they are able to disrupt zinc finger parts of nucleocapsid. Antiviral activity of these dinucleotides were tested in vitro against HIV-1, HIV-2, HSV-1, HSV-2, CMV, VZV and EBV but in no case EC50 values inferior to 10 µM was found.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

TRONCHET, Jean Marcel Julien et al. Nucleosides and acyclonucleosides bearing a N-hydroxyureido group. In: Carbohydrate letters, 1996, vol. 2, n° 12, p. 101–108.

Main files (1)

Article (Published version)

Identifiers

  • PID : unige:2823

Journal ISSN

1029-2438
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Technical informations

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21/09/2009 16:03:45

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