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Title

Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis

Authors
Saxena, R.
Zhang, S.
Terracciano, L.
Sauter, G.
Chadhuri, A.
Penetrante, R.
Published in Journal of Clinical Pathology. 2007, vol. 60, no. 6, p. 709-714
Abstract BACKGROUND: Pax-5 belongs to the Pax gene family transcription factors that play an important role in organogenesis and in B cell ontogeny. It is expressed in B cell non-Hodgkin's lymphoma (B-NHL), Hodgkin's lymphoma (HL) and neuroendocrine carcinomas. However, its expression in other tumour types is not fully explored. Aims and methods: To determine Pax-5 expression in other tumour types, immunohistochemistry was performed on 3758 benign and malignant tumours using multiple tumour microarrays, as well as on whole sections. RESULTS: Pax-5 was expressed in 108/118 (91.5%) B-NHLs, in 60/70 (85.7%) HLs and in 0/7 T cell lymphomas. In addition, Pax-5 was seen in 24/34 (70.6%) Merkel cell carcinomas, 42/53 (79.2%) small cell carcinomas, 1/164 (0.6%) breast carcinomas, 2/204 (1%) endometrial adenocarcinomas and 1/452 (0.2%) urothelial carcinoma of the bladder. CONCLUSION: Despite its expression in a small subset of malignancies of epithelial origin, Pax-5 is still a good and reliable immunomarker in diagnosing B-NHL, HL and neuroendocrine carcinomas.
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PMID: 16837628
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MHAWECH-FAUCEGLIA, Paulette et al. Pax-5 immunoexpression in various types of benign and malignant tumours: a high-throughput tissue microarray analysis. In: Journal of Clinical Pathology, 2007, vol. 60, n° 6, p. 709-714. https://archive-ouverte.unige.ch/unige:28159

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Deposited on : 2013-05-28

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