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Scientific article
English

Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up

Published inEuropean journal of surgical oncology, vol. 32, no. 4, p. 439-444
Publication date2006
Abstract

AIMS: The study was designed to evaluate Raf1, Aurora-A/STK15 and E-cadherin (E-CD) protein expression and their prognostic value in patients with pTa/pT1 tumours. MATERIALS AND METHODS: A tissue microarray of 105 pTa, and 141 pT1 tumours was constructed and sections were immunostained with these three antibodies. RESULTS: There were significant associations between Raf1 overexpression and tumour grade (p = 0.03), between Aurora-A overexpression/alterations of E-CD and tumour grade and stage (p < 0.001 and p < 0.001). In multiple Cox regression analysis, moderate/strong expression of E-CD seemed to be an independent factor in predicting slower tumour progression (p = 0.003) and Aurora-A overexpression (p = 0.022) displays an independent value in predicting tumour recurrences. CONCLUSION: Evaluation of E-CD and Aurora-A expressions in tissue of patients with pTa/pT1 UC have been proven to be useful in predicting tumours behavior and Raf1 protein expression seemed to have no potential use in this regard.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Bladder Neoplasms/*metabolism/pathology
  • Cadherins/*biosynthesis
  • Carcinoma/*metabolism/pathology
  • Comparative Study
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Prognosis
  • Protein-Serine-Threonine Kinases/*biosynthesis
  • Proto-Oncogene Proteins c-raf/*biosynthesis
  • Retrospective Studies
  • Tissue Array Analysis
  • Tumor Markers, Biological/*biosynthesis
  • Urothelium/pathology
Citation (ISO format)
MHAWECH-FAUCEGLIA, Paulette et al. Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up. In: European journal of surgical oncology, 2006, vol. 32, n° 4, p. 439–444. doi: 10.1016/j.ejso.2006.01.018
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ISSN of the journal0748-7983
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