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Title

FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer
Authors
Mhawech-fauceglia, Paulette
Cheney, R. T.
Fischer, G.
Beck, A.
Herrmann, François
Published in European Journal of Surgical Oncology. 2006, vol. 32, no. 2, p. 231-237
Abstract AIMS: This study is designed to evaluate the expression and prognostic value of FGFR3 protein expression in patients with pTa/pT1 tumours and to determine the significance of the combinations of FGFR3 and p53 protein expressions in bladder pathogenesis. MATERIALS AND METHODS: A tissue microarray (TMA) of 107 pTa, and 147 pT1 tumours was constructed. The TMA sections were immunostained with FGFR3 and p53 monoclonal antibodies. RESULTS: There were significant associations between loss of FGFR3 and tumour stage (p<0.001) and grade (p<0.001) and between p53 overexpression and tumour stage and grade (p<0.001 and p<0.001, respectively). There was no association between FGFR3 and p53 proteins (p=0.107). In addition, tumours with FGFR3+/p53- phenotype have slower recurrence rate than other (FGFR3+/p53+, FGFR3-/p53- and FGFR3-/p53+). CONCLUSION: 1-FGFR3 expression is significantly associated with two important prognostic factors; stage and grade. 2-FGFR3 protein expression is not an independent predictive factor for pTa/pT1 tumour recurrence and progression. 3-Tumours with FGFR3+/p53- phenotype seem to have a distinctive pathway in bladder tumorigenesis.
Keywords Adult — Aged — Aged, 80 and over — Analysis of Variance — Antibodies, Monoclonal/diagnostic use — Carcinoma, Transitional Cell/*chemistry/pathology/therapy — Chemotherapy, Adjuvant — Disease Progression — Female — Follow-Up Studies — Gene Expression Regulation, Neoplastic — Humans — Male — Middle Aged — Neoplasm Recurrence, Local/chemistry — Neoplasm Staging — Phenotype — Prognosis — Receptor, Fibroblast Growth Factor, Type 3/*analysis/immunology — Retrospective Studies — Tumor Suppressor Protein p53/*analysis/immunology — Urinary Bladder Neoplasms/*chemistry/pathology/therapy — Urologic Surgical Procedures
Identifiers
PMID: 16412606
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Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne générale, de réhabilitation et de gériatrie
Citation
(ISO format) 		MHAWECH-FAUCEGLIA, Paulette et al. FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer. In: European Journal of Surgical Oncology, 2006, vol. 32, n° 2, p. 231-237. https://archive-ouverte.unige.ch/unige:28152

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Deposited on : 2013-05-28

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