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Scientific article
English

FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer

Published inEuropean journal of surgical oncology, vol. 32, no. 2, p. 231-237
Publication date2006
Abstract

AIMS: This study is designed to evaluate the expression and prognostic value of FGFR3 protein expression in patients with pTa/pT1 tumours and to determine the significance of the combinations of FGFR3 and p53 protein expressions in bladder pathogenesis. MATERIALS AND METHODS: A tissue microarray (TMA) of 107 pTa, and 147 pT1 tumours was constructed. The TMA sections were immunostained with FGFR3 and p53 monoclonal antibodies. RESULTS: There were significant associations between loss of FGFR3 and tumour stage (p<0.001) and grade (p<0.001) and between p53 overexpression and tumour stage and grade (p<0.001 and p<0.001, respectively). There was no association between FGFR3 and p53 proteins (p=0.107). In addition, tumours with FGFR3+/p53- phenotype have slower recurrence rate than other (FGFR3+/p53+, FGFR3-/p53- and FGFR3-/p53+). CONCLUSION: 1-FGFR3 expression is significantly associated with two important prognostic factors; stage and grade. 2-FGFR3 protein expression is not an independent predictive factor for pTa/pT1 tumour recurrence and progression. 3-Tumours with FGFR3+/p53- phenotype seem to have a distinctive pathway in bladder tumorigenesis.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Antibodies, Monoclonal/diagnostic use
  • Carcinoma, Transitional Cell/*chemistry/pathology/therapy
  • Chemotherapy, Adjuvant
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local/chemistry
  • Neoplasm Staging
  • Phenotype
  • Prognosis
  • Receptor, Fibroblast Growth Factor, Type 3/*analysis/immunology
  • Retrospective Studies
  • Tumor Suppressor Protein p53/*analysis/immunology
  • Urinary Bladder Neoplasms/*chemistry/pathology/therapy
  • Urologic Surgical Procedures
Citation (ISO format)
MHAWECH-FAUCEGLIA, Paulette et al. FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer. In: European journal of surgical oncology, 2006, vol. 32, n° 2, p. 231–237. doi: 10.1016/j.ejso.2005.11.018
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ISSN of the journal0748-7983
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