UNIGE document Scientific Article
previous document  unige:28152  next document
add to browser collection

FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer

Cheney, R. T.
Fischer, G.
Beck, A.
Published in European journal of surgical oncology. 2006, vol. 32, no. 2, p. 231-237
Abstract AIMS: This study is designed to evaluate the expression and prognostic value of FGFR3 protein expression in patients with pTa/pT1 tumours and to determine the significance of the combinations of FGFR3 and p53 protein expressions in bladder pathogenesis. MATERIALS AND METHODS: A tissue microarray (TMA) of 107 pTa, and 147 pT1 tumours was constructed. The TMA sections were immunostained with FGFR3 and p53 monoclonal antibodies. RESULTS: There were significant associations between loss of FGFR3 and tumour stage (p<0.001) and grade (p<0.001) and between p53 overexpression and tumour stage and grade (p<0.001 and p<0.001, respectively). There was no association between FGFR3 and p53 proteins (p=0.107). In addition, tumours with FGFR3+/p53- phenotype have slower recurrence rate than other (FGFR3+/p53+, FGFR3-/p53- and FGFR3-/p53+). CONCLUSION: 1-FGFR3 expression is significantly associated with two important prognostic factors; stage and grade. 2-FGFR3 protein expression is not an independent predictive factor for pTa/pT1 tumour recurrence and progression. 3-Tumours with FGFR3+/p53- phenotype seem to have a distinctive pathway in bladder tumorigenesis.
Keywords AdultAgedAged, 80 and overAnalysis of VarianceAntibodies, Monoclonal/diagnostic useCarcinoma, Transitional Cell/*chemistry/pathology/therapyChemotherapy, AdjuvantDisease ProgressionFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm Recurrence, Local/chemistryNeoplasm StagingPhenotypePrognosisReceptor, Fibroblast Growth Factor, Type 3/*analysis/immunologyRetrospective StudiesTumor Suppressor Protein p53/*analysis/immunologyUrinary Bladder Neoplasms/*chemistry/pathology/therapyUrologic Surgical Procedures
PMID: 16412606
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
MHAWECH-FAUCEGLIA, Paulette et al. FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer. In: European journal of surgical oncology, 2006, vol. 32, n° 2, p. 231-237. doi: 10.1016/j.ejso.2005.11.018 https://archive-ouverte.unige.ch/unige:28152

453 hits

0 download


Deposited on : 2013-05-28

Export document
Format :
Citation style :