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Title

Prognostic significance of neuron-associated protein expression in non-muscle-invasive urothelial bladder cancer
Authors
Mhawech-fauceglia, Paulette
Allali, Gilles
Cheney, R. T.
Groth, J.
Herrmann, François
Published in Journal of Clinical Pathology. 2009, vol. 62, no. 8, p. 710-714
Abstract BACKGROUND: Numerous novel genes have been identified in urothelial bladder cancer (UBC); genes including ninjurin, synuclein and neuropilin seem to be associated with invasive tumours and aggressive behaviour. AIMS: To define the protein expression of these biomarkers and to reveal their prognostic value in a large series of superficial (pTa) and minimally invasive (pT1) cases of UBC with a long and adequate follow-up. METHODS: Tissue microarray was done on 183 paraffin-embedded tumour tissues (pTa 81, pT1 102). Statistical analysis was performed to define the association between each of these biomarkers, clinical data and tumour outcomes. RESULTS: There was a statistically significant association between synuclein expression and tumour stage (p = 0.029). Ninjurin expression was significantly associated with tumour progression in univariate analysis. Tumour grade seemed to have an independent value in predicting tumour recurrence and progression. CONCLUSION: Tumours with strong synuclein expressions are more likely to be more advanced tumours (pT1). Tumours expressing ninjurin tend to progress slower than those with no ninjurin expressions. Synuclein and neuropilin failed to show any value in predicting tumour behaviour.
Keywords Adult — Aged — Aged, 80 and over — Cell Adhesion Molecules, Neuronal/metabolism — Cytoplasm/metabolism — Disease Progression — Epidemiologic Methods — Female — Humans — Male — Middle Aged — Neoplasm Invasiveness — Neoplasm Proteins/metabolism — Neoplasm Staging — Nerve Growth Factors/metabolism — Nerve Tissue Proteins/*metabolism — Prognosis — Synucleins/metabolism — Tissue Array Analysis/methods — Tumor Markers, Biological/*metabolism — Urinary Bladder Neoplasms/*metabolism/pathology
Identifiers
PMID: 19638542
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Other version: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19638542
Structures
Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Citation
(ISO format) 		MHAWECH-FAUCEGLIA, Paulette et al. Prognostic significance of neuron-associated protein expression in non-muscle-invasive urothelial bladder cancer. In: Journal of Clinical Pathology, 2009, vol. 62, n° 8, p. 710-714. doi: 10.1136/jcp.2009.066159 https://archive-ouverte.unige.ch/unige:28151

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Deposited on : 2013-05-28

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