Scientific article

Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children

Published inJournal of the American College of Cardiology, vol. 54, no. 25, p. 2396-2406
Publication date2009

OBJECTIVES: The aim of this study was to determine the effects of physical activity on systemic blood pressure (BP) and early markers of atherosclerosis in pre-pubertal obese children. BACKGROUND: Hypertension and endothelial dysfunction are premature complications of obesity. METHODS: We performed a 3-month randomized controlled trial with a modified crossover design: 44 pre-pubertal obese children (age 8.9 + or - 1.5 years) were randomly assigned (1:1) to an exercise (n = 22) or a control group (n = 22). We recruited 22 lean children (age 8.5 + or - 1.5 years) for baseline comparison. The exercise group trained 60 min 3 times/week during 3 months, whereas control subjects remained relatively inactive. Then, both groups trained twice/week during 3 months. We assessed changes at 3 and 6 months in office and 24-h BP, arterial intima-media thickness (IMT) and stiffness, endothelial function (flow-mediated dilation), body mass index (BMI), body fat, cardiorespiratory fitness (maximal oxygen consumption [VO(2)max]), physical activity, and biological markers. RESULTS: Obese children had higher BP, arterial stiffness, body weight, BMI, abdominal fat, insulin resistance indexes, and C-reactive protein levels, and lower flow-mediated dilation, VO(2)max, physical activity, and high-density lipoprotein cholesterol levels than lean subjects. At 3 months, we observed significant changes in 24-h systolic BP (exercise -6.9 + or - 13.5 mm Hg vs. control 3.8 + or - 7.9 mm Hg, -0.8 + or - 1.5 standard deviation score [SDS] vs. 0.4 + or - 0.8 SDS), diastolic BP (-0.5 + or - 1.0 SDS vs. 0 + or - 1.4 SDS), hypertension rate (-12% vs. -1%), office BP, BMI z-score, abdominal fat, and VO(2)max. At 6 months, change differences in arterial stiffness and IMT were significant. CONCLUSIONS: A regular physical activity program reduces BP, arterial stiffness, and abdominal fat; increases cardiorespiratory fitness; and delays arterial wall remodeling in pre-pubertal obese children. (Effects of Aerobic Exercise Training on Arterial Function and Insulin Resistance Syndrome in Obese Children: A Randomized Controlled Trial; NCT00801645).

  • Atherosclerosis/*blood/*physiopathology
  • Biological Markers/blood
  • Body Fat Distribution
  • Body Height/physiology
  • Body Mass Index
  • Body Weight/physiology
  • Carotid Artery, Common/ultrasonography
  • Child
  • Cholesterol, HDL/blood
  • Cross-Over Studies
  • Endothelium, Vascular/physiology/ultrasonography
  • Exercise/*physiology
  • Exercise Tolerance/physiology
  • Female
  • Humans
  • Hypertension/physiopathology/*therapy
  • Insulin Resistance/physiology
  • Male
  • Obesity/physiopathology/*therapy
  • Oxygen Consumption/physiology
  • Physical Fitness/physiology
  • Puberty/physiology
  • Regional Blood Flow/physiology
  • Tunica Intima/ultrasonography
  • Tunica Media/ultrasonography
  • Vasodilation/physiology
Citation (ISO format)
FARPOUR-LAMBERT, Nathalie et al. Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children. In: Journal of the American College of Cardiology, 2009, vol. 54, n° 25, p. 2396–2406. doi: 10.1016/j.jacc.2009.08.030
Main files (1)
ISSN of the journal0735-1097

Technical informations

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