UNIGE document Scientific Article
previous document  unige:2801  next document
add to browser collection
Title

A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes

Authors
Grigorov, Martin G.
Tronchet, Jean M.J.
Jefford, Charles William
Milhous, Wilbur K.
Maric, Djordje M.
Published in Journal of Chemical Information and Computer Sciences. 1997, vol. 37, no. 1, p. 124-130
Abstract The antimalarial activity of a series of synthetic 1,2,4-trioxanes is correlated with molecular structure by using a pharmacophore search method (CATALYST). The technique is shown to have predictive accuracy and confirms that docking between an active trioxane and the receptor, heme, is the crucial step for drug action.
Keywords MalariaArtemisininHeme3D-QSARCatalyst
Identifiers
Full text
Structures
Research group Groupe Weber
Citation
(ISO format)
GRIGOROV, Martin G. et al. A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes. In: Journal of Chemical Information and Computer Sciences, 1997, vol. 37, n° 1, p. 124-130. https://archive-ouverte.unige.ch/unige:2801

201 hits

0 download

Update

Deposited on : 2009-09-21

Export document
Format :
Citation style :