A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes
|Published in||Journal of chemical information and computer sciences. 1997, vol. 37, no. 1, p. 124-130|
|Abstract||The antimalarial activity of a series of synthetic 1,2,4-trioxanes is correlated with molecular structure by using a pharmacophore search method (CATALYST). The technique is shown to have predictive accuracy and confirms that docking between an active trioxane and the receptor, heme, is the crucial step for drug action.|
|Keywords||Malaria — Artemisinin — Heme — 3D-QSAR — Catalyst|
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|Research group||Groupe Weber|
|GRIGOROV, Martin et al. A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes. In: Journal of chemical information and computer sciences, 1997, vol. 37, n° 1, p. 124-130. doi: 10.1021/ci9601168 https://archive-ouverte.unige.ch/unige:2801|