en
Scientific article
English

A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes

Published inJournal of chemical information and computer sciences, vol. 37, no. 1, p. 124-130
Publication date1997
Abstract

The antimalarial activity of a series of synthetic 1,2,4-trioxanes is correlated with molecular structure by using a pharmacophore search method (CATALYST). The technique is shown to have predictive accuracy and confirms that docking between an active trioxane and the receptor, heme, is the crucial step for drug action.

Keywords
  • Malaria
  • Artemisinin
  • Heme
  • 3D-QSAR
  • Catalyst
Research group
Citation (ISO format)
GRIGOROV, Martin et al. A QSAR study of the antimalarial activity of some synthetic 1,2,4-trioxanes. In: Journal of chemical information and computer sciences, 1997, vol. 37, n° 1, p. 124–130. doi: 10.1021/ci9601168
Identifiers
ISSN of the journal0095-2338
511views
0downloads

Technical informations

Creation09/21/2009 4:03:34 PM
First validation09/21/2009 4:03:34 PM
Update time03/14/2023 3:12:02 PM
Status update03/14/2023 3:12:02 PM
Last indexation01/15/2024 6:48:42 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack