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Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state

Published in Proceedings of the National Academy of Sciences. 2013, vol. 110, no. 3, p. 1113-1118
Abstract Plants require the UV-B photoreceptor UV resistance locus 8 (UVR8) for acclimation and survival in sunlight. Upon UV-B perception, UVR8 switches instantaneously from a homodimeric to monomeric configuration, which leads to interaction with the key signaling protein constitutively photomorphogenic 1 (COP1) and induction of UV-B-protective responses. Here, we show that UVR8 monomerization is reversible in vivo, restoring the homodimeric ground state. We also demonstrate that the UVR8-interacting proteins repressor of UV-B photomorphogenesis (RUP)1 and RUP2 mediate UVR8 redimerization independently of COP1. UVR8 redimerization consequently disrupts the UVR8-COP1 interaction, which halts signaling. Our results identify a key role of RUP1- and RUP2-mediated UVR8 redimerization in photoreceptor inactivation, a crucial process that regenerates reactivatable UVR8 homodimers.
Keywords Arabidopsis/genetics/metabolism/radiation effectsArabidopsis Proteins/chemistry/genetics/metabolismChromosomal ProteinsNon-Histone/chemistry/genetics/metabolismGenesPlantMutationPhotoreceptorsPlant/chemistry/genetics/metabolismProtein Multimerization/radiation effectsProtein StructureQuaternary/radiation effectsRepressor Proteins/genetics/metabolismSignal Transduction/radiation effectsUbiquitin-Protein Ligases/genetics/metabolismUltraviolet Rays
PMID: 23277547
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HEIJDE, Marc, ULM, Roman. Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state. In: Proceedings of the National Academy of Sciences, 2013, vol. 110, n° 3, p. 1113-1118. https://archive-ouverte.unige.ch/unige:27984

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Deposited on : 2013-05-27

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