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Scientific Article
unige:27984 
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Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state |
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| Authors | ||
| Published in | Proceedings of the National Academy of Sciences. 2013, vol. 110, no. 3, p. 1113-1118 | |
| Abstract | Plants require the UV-B photoreceptor UV resistance locus 8 (UVR8) for acclimation and survival in sunlight. Upon UV-B perception, UVR8 switches instantaneously from a homodimeric to monomeric configuration, which leads to interaction with the key signaling protein constitutively photomorphogenic 1 (COP1) and induction of UV-B-protective responses. Here, we show that UVR8 monomerization is reversible in vivo, restoring the homodimeric ground state. We also demonstrate that the UVR8-interacting proteins repressor of UV-B photomorphogenesis (RUP)1 and RUP2 mediate UVR8 redimerization independently of COP1. UVR8 redimerization consequently disrupts the UVR8-COP1 interaction, which halts signaling. Our results identify a key role of RUP1- and RUP2-mediated UVR8 redimerization in photoreceptor inactivation, a crucial process that regenerates reactivatable UVR8 homodimers. | |
| Keywords | Arabidopsis/genetics/metabolism/radiation effects — Arabidopsis Proteins/chemistry/genetics/metabolism — Chromosomal Proteins — Non-Histone/chemistry/genetics/metabolism — Genes — Plant — Mutation — Photoreceptors — Plant/chemistry/genetics/metabolism — Protein Multimerization/radiation effects — Protein Structure — Quaternary/radiation effects — Repressor Proteins/genetics/metabolism — Signal Transduction/radiation effects — Ubiquitin-Protein Ligases/genetics/metabolism — Ultraviolet Rays | |
| Identifiers | PMID: 23277547 | |
| Full text |
Article (Published version) (1.5 MB) - Limited access to UNIGE Other version: http://www.pnas.org/content/110/3/1113.full.pdf+html |
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| Structures | ||
| Citation (ISO format) | HEIJDE, Marc, ULM, Roman. Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state. In: Proceedings of the National Academy of Sciences, 2013, vol. 110, n° 3, p. 1113-1118. https://archive-ouverte.unige.ch/unige:27984 |
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