Detection of ATP by "in line" 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs' kidneys

Lazeyras, François; Buehler, Leo Hans; Vallée, Jean-Paul; Hergt, Martin; Nastasi, Antonio; Ruttimann, Raphael; Morel, Philippe; Buchs, Jean-Bernard

doi:10.1007/s10334-012-0319-6

Scientific article

English

Detection of ATP by "in line" 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs' kidneys

ContributorsLazeyras, François; Buehler, Leo Hans; Vallée, Jean-Paul

; Hergt, Martin; Nastasi, Antonio; Ruttimann, Raphael; Morel, Philippe; Buchs, Jean-Bernard

Published inMagma, vol. 25, no. 5, p. 391-399

Collection

Open Access - Licence nationale Springer

Publication date2012

Abstract

To demonstrate that adenosine triphosphate (ATP), which provides a valuable biomarker for kidney viability in the context of donation after cardiac death (DCD) transplantation, can be detected by means of (31)P magnetic resonance spectroscopy (MRS) if kidneys are perfused with oxygenated hypothermic pulsatile perfusion (O(2)+HPP).

Keywords

Adenosine Triphosphate/analysis/chemistry
Animals
Cell Survival
Death
Equipment Design
Ischemia/pathology
Kidney/metabolism
Kidney Transplantation/methods
Magnetic Resonance Imaging/methods
Magnetic Resonance Spectroscopy/methods
Organ Preservation/methods
Oxygen/chemistry
Phosphorus Isotopes/pharmacology
Pulsatile Flow
Swine
Time Factors

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

LAZEYRAS, François et al. Detection of ATP by ‘in line’ 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs” kidneys. In: Magma, 2012, vol. 25, n° 5, p. 391–399. doi: 10.1007/s10334-012-0319-6

Article (Published version)

Identifiers

PID : unige:27971
DOI : 10.1007/s10334-012-0319-6
PMID : 22644411

Journal ISSN0968-5243

848views

344downloads

Creation22/05/2013 12:46:00

First validation22/05/2013 12:46:00

Update14/03/2023 20:11:31

Status update14/03/2023 20:11:31

Last indexation30/10/2024 09:28:14

Archive ouverte UNIGE

Detection of ATP by "in line" 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs' kidneys

Technical informations