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Detection of ATP by "in line" 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs' kidneys

ContributorsLazeyras, François; Buehler, Leo Hans; Vallée, Jean-Paulorcid; Hergt, Martin; Nastasi, Antonio; Ruttimann, Raphael; Morel, Philippe; Buchs, Jean-Bernard
Published inMagma, vol. 25, no. 5, p. 391-399
Collection
  • Open Access - Licence nationale Springer
Publication date2012
Abstract

To demonstrate that adenosine triphosphate (ATP), which provides a valuable biomarker for kidney viability in the context of donation after cardiac death (DCD) transplantation, can be detected by means of (31)P magnetic resonance spectroscopy (MRS) if kidneys are perfused with oxygenated hypothermic pulsatile perfusion (O(2)+HPP).

Keywords
  • Adenosine Triphosphate/analysis/chemistry
  • Animals
  • Cell Survival
  • Death
  • Equipment Design
  • Ischemia/pathology
  • Kidney/metabolism
  • Kidney Transplantation/methods
  • Magnetic Resonance Imaging/methods
  • Magnetic Resonance Spectroscopy/methods
  • Organ Preservation/methods
  • Oxygen/chemistry
  • Phosphorus Isotopes/pharmacology
  • Pulsatile Flow
  • Swine
  • Time Factors
Affiliation entities
Research groups
Citation (ISO format)
LAZEYRAS, François et al. Detection of ATP by ‘in line’ 31P magnetic resonance spectroscopy during oxygenated hypothermic pulsatile perfusion of pigs” kidneys. In: Magma, 2012, vol. 25, n° 5, p. 391–399. doi: 10.1007/s10334-012-0319-6
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Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0968-5243
730views
254downloads

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