UNIGE document Scientific Article
previous document  unige:27946  next document
add to browser collection
Title

Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes

Authors
Sebbag, Mireille
Foulquier, Céline
Serre, Guy
Published in European Cytokine Network. 2012, vol. 23, no. 2, p. 36-44
Abstract The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to "citrullinated" proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two - PAD2 and PAD4 - are expressed in RA synovial tissue. Within this tissue, the activation of macrophages and fibroblasts mediated by T-cell contact or driven by cytokines plays a prominent part in the pathogenesis. We wanted to determine whether cytokine stimulation and contact with T cells could play a role in PAD expression by peripheral blood monocytes and fibroblastic synoviocytes.
Keywords Arthritis, Rheumatoid/immunologyAutoantibodies/metabolismCells, CulturedFibroblasts/metabolismHumansHydrolases/biosynthesis/geneticsInterferon-beta/immunologyInterleukin-1beta/immunologyLymphocyte ActivationMacrophage ActivationMacrophages/immunology/metabolismMonocytes/immunology/metabolismRNA, Messenger/genetics/metabolismSynovial Membrane/cytology/metabolismT-Lymphocytes/immunologyTranscription, GeneticUp-Regulation
Identifiers
PMID: 22614825
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Structures
Citation
(ISO format)
FERRARI-LACRAZ, Sylvie et al. Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes. In: European Cytokine Network, 2012, vol. 23, n° 2, p. 36-44. https://archive-ouverte.unige.ch/unige:27946

143 hits

0 download

Update

Deposited on : 2013-05-21

Export document
Format :
Citation style :