en
Scientific article
English

Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes

Published inEuropean cytokine network, vol. 23, no. 2, p. 36-44
Publication date2012
Abstract

The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to "citrullinated" proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two - PAD2 and PAD4 - are expressed in RA synovial tissue. Within this tissue, the activation of macrophages and fibroblasts mediated by T-cell contact or driven by cytokines plays a prominent part in the pathogenesis. We wanted to determine whether cytokine stimulation and contact with T cells could play a role in PAD expression by peripheral blood monocytes and fibroblastic synoviocytes.

Keywords
  • Arthritis, Rheumatoid/immunology
  • Autoantibodies/metabolism
  • Cells, Cultured
  • Fibroblasts/metabolism
  • Humans
  • Hydrolases/biosynthesis/genetics
  • Interferon-beta/immunology
  • Interleukin-1beta/immunology
  • Lymphocyte Activation
  • Macrophage Activation
  • Macrophages/immunology/metabolism
  • Monocytes/immunology/metabolism
  • RNA, Messenger/genetics/metabolism
  • Synovial Membrane/cytology/metabolism
  • T-Lymphocytes/immunology
  • Transcription, Genetic
  • Up-Regulation
Citation (ISO format)
FERRARI-LACRAZ, Sylvie et al. Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes. In: European cytokine network, 2012, vol. 23, n° 2, p. 36–44. doi: 10.1684/ecn.2012.0303
Identifiers
ISSN of the journal1148-5493
504views
0downloads

Technical informations

Creation04/25/2013 11:01:00 AM
First validation04/25/2013 11:01:00 AM
Update time03/14/2023 8:11:23 PM
Status update03/14/2023 8:11:23 PM
Last indexation01/16/2024 1:40:17 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack