Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes
|Published in||European Cytokine Network. 2012, vol. 23, no. 2, p. 36-44|
|Abstract||The antigenic targets of the rheumatoid arthritis (RA)-associated autoantibodies to "citrullinated" proteins are generated following citrullination by a peptidylarginine deiminase (PAD). Of the five PAD isotypes, two - PAD2 and PAD4 - are expressed in RA synovial tissue. Within this tissue, the activation of macrophages and fibroblasts mediated by T-cell contact or driven by cytokines plays a prominent part in the pathogenesis. We wanted to determine whether cytokine stimulation and contact with T cells could play a role in PAD expression by peripheral blood monocytes and fibroblastic synoviocytes.|
|Keywords||Arthritis, Rheumatoid/immunology — Autoantibodies/metabolism — Cells, Cultured — Fibroblasts/metabolism — Humans — Hydrolases/biosynthesis/genetics — Interferon-beta/immunology — Interleukin-1beta/immunology — Lymphocyte Activation — Macrophage Activation — Macrophages/immunology/metabolism — Monocytes/immunology/metabolism — RNA, Messenger/genetics/metabolism — Synovial Membrane/cytology/metabolism — T-Lymphocytes/immunology — Transcription, Genetic — Up-Regulation|
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|FERRARI-LACRAZ, Sylvie et al. Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes. In: European Cytokine Network, 2012, vol. 23, n° 2, p. 36-44. doi: 10.1684/ecn.2012.0303 https://archive-ouverte.unige.ch/unige:27946|