UNIGE document Scientific Article
previous document  unige:27926  next document
add to browser collection

Chiral Selectivity in the Binding of [4]Helicene Derivatives to Double-Stranded DNA

Hammarson, Martin
Albinsson, Bo
show hidden authors show all authors [1 - 9]
Published in Chemistry. 2013, vol. 19, no. 22, p. 7173-7180
Abstract The interaction of a series of chiral cationic [4]helicene derivatives, which differ by their substituents, with double-stranded DNA has been investigated by using a combination of spectroscopic techniques, including time-resolved fluorescence, fluorescence anisotropy, and linear dichroism. Addition of DNA to helicene solutions results to a hypochromic shift of the visible absorption bands, an increase of fluorescence quantum yield and lifetime, a slowing down of fluorescence anisotropy decay, and a linear dichroism in flow-oriented DNA, which unambiguously points to the binding of these dyes to DNA. Both helicene monomers and dimeric aggregates, which form at higher concentration, bind to DNA, the former most probably upon intercalation and the latter upon groove binding. The binding constant depends substantially on the dye substituents and is, in all cases, larger with the M than the P enantiomer, by factors ranging from 1.2 to 2.3, depending on the dye.
Keywords chiralitycircular dichroismDNA recognitionfluorescent probeshelical structurestime-resolved spectroscopy
Full text
Article (Published version) (969 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
KEL, Oksana et al. Chiral Selectivity in the Binding of [4]Helicene Derivatives to Double-Stranded DNA. In: Chemistry, 2013, vol. 19, n° 22, p. 7173-7180. doi: 10.1002/chem.201203915 https://archive-ouverte.unige.ch/unige:27926

624 hits



Deposited on : 2013-05-21

Export document
Format :
Citation style :