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Monoamine oxidase A down-regulation contributes to high metanephrine concentration in pheochromocytoma

Grouzmann, Eric
Matter, Maurice
Bilz, Stefan
Herren, Adeline
Henzen, Christophe
Kim, Kwang-Soo
Zulewski, Henryk
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Published in Journal of Clinical Endocrinology and Metabolism. 2012, vol. 97, no. 8, p. 2773-81
Abstract The high diagnostic performance of plasma-free metanephrines (metanephrine and normetanephrine) (MN) for pheochromocytoma (PHEO) results from the tumoral expression of catechol-O-methyltransferase (COMT), the enzyme involved in O-methylation of catecholamines (CAT). Intriguingly, metanephrine, in contrast to epinephrine, is not remarkably secreted during a stress in hypertensive or normotensive subjects, whereas in PHEO patients CAT and MN are both raised to high levels. Because epinephrine and metanephrine are almost exclusively produced by the adrenal medulla, this suggests distinct CAT metabolism in chromaffin cells and pheochromocytes.
Keywords AdolescentAdrenal Gland Neoplasms/metabolismAdrenal Medulla/metabolismAdultAgedCatechol O-Methyltransferase/analysis/physiologyCatecholamines/metabolismDown-RegulationFemaleGene Expression Regulation, EnzymologicHumansMaleMetanephrine/analysis/metabolismMiddle AgedMonoamine Oxidase/analysis/genetics/physiologyPheochromocytoma/metabolism
PMID: 22569243
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Research groups Chirurgie thoracique et chirurgie endocrinologique (573)
Mésothéliome pleural malin (944)
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GROUZMANN, Eric et al. Monoamine oxidase A down-regulation contributes to high metanephrine concentration in pheochromocytoma. In: Journal of Clinical Endocrinology & Metabolism, 2012, vol. 97, n° 8, p. 2773-81. https://archive-ouverte.unige.ch/unige:27872

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Deposited on : 2013-05-15

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