Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study

Vuilleumier, Pascal; Besson, Marie; Desmeules, Jules Alexandre; Arendt-Nielsen, Lars; Curatolo, Michele

doi:10.1371/journal.pone.0043896

Scientific article

Open access

English

Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study

ContributorsVuilleumier, Pascal; Besson, Marie; Desmeules, Jules Alexandre; Arendt-Nielsen, Lars; Curatolo, Michele

Published inPloS one, vol. 8, no. 3, e43896

Publication date2013

Abstract

Compounds that act on GABA-receptors produce anti-hyperalgesia in animal models, but little is known on their effects in humans. The aim of this study was to explore the potential usefulness of GABA-agonism for the control of pain in humans. Two agonists at the benzodiazepine-binding site of GABAA-receptors (clobazam and clonazepam) were studied using multiple experimental pain tests. Positive results would support further investigation of GABA agonism for the control of clinical pain.

Affiliation

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research group

Groupe Desmeules Jules (pharmacologie/toxicologie) (567)

Funding

Swiss National Science Foundation - Novel approaches to the treatment of chronic pain: translating recent discoveries in painrelated neural plasticity to clinical practice- Na+-channel modulators and subtype-selective GABAA receptor ligands

Citation (ISO format)

VUILLEUMIER, Pascal et al. Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. In: PloS one, 2013, vol. 8, n° 3, p. e43896. doi: 10.1371/journal.pone.0043896

Article (Published version)

CC BY

Identifiers

PID : unige:27791
DOI : 10.1371/journal.pone.0043896
PMID : 23554851

ISSN of the journal1932-6203

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Creation10/05/2013 12:26:00

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Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study

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