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Access to congested quaternary centers by Pd-catalyzed intermolecular γ-arylation of unactivated α,β-unsaturated aldehydes

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Published in Chemical Science. 2013, vol. 4, no. 6, p. 2619-2624
Abstract A palladium-catalyzed intermolecular γ-arylation of γ-branched α,β-unsaturated aldehydes has been developed. The reaction allows congested quaternary centers to be forged on a remote position from the carbonyl group, affording a variety of products in high yield and with consistently high stereoselectivity using very low catalyst loadings. The synthetic utility of the products has been highlighted by a series of derivatizations and the potential of the method to be extended to remote ε-functionalization has been demonstrated.
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Other version: http://xlink.rsc.org/?DOI=c3sc50806d
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FRANZONI, Ivan, GUENEE, Laure, MAZET, Clement. Access to congested quaternary centers by Pd-catalyzed intermolecular γ-arylation of unactivated α,β-unsaturated aldehydes. In: Chemical Science, 2013, vol. 4, n° 6, p. 2619-2624. https://archive-ouverte.unige.ch/unige:27741

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Deposited on : 2013-05-08

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