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Scientific article
English

Access to congested quaternary centers by Pd-catalyzed intermolecular γ-arylation of unactivated α,β-unsaturated aldehydes

Published inChemical science, vol. 4, no. 6, p. 2619-2624
Publication date2013
Abstract

A palladium-catalyzed intermolecular γ-arylation of γ-branched α,β-unsaturated aldehydes has been developed. The reaction allows congested quaternary centers to be forged on a remote position from the carbonyl group, affording a variety of products in high yield and with consistently high stereoselectivity using very low catalyst loadings. The synthetic utility of the products has been highlighted by a series of derivatizations and the potential of the method to be extended to remote ε-functionalization has been demonstrated.

Citation (ISO format)
FRANZONI, Ivan, GUENEE, Laure, MAZET, Clement. Access to congested quaternary centers by Pd-catalyzed intermolecular γ-arylation of unactivated α,β-unsaturated aldehydes. In: Chemical science, 2013, vol. 4, n° 6, p. 2619–2624. doi: 10.1039/c3sc50806d
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ISSN of the journal2041-6520
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Creation05/07/2013 8:33:00 PM
First validation05/07/2013 8:33:00 PM
Update time03/14/2023 8:10:14 PM
Status update03/14/2023 8:10:14 PM
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