en
Scientific article
Review
English

Detection of anti-HLA antibodies by solid-phase assay in kidney transplantation: friend or foe?

Published inTissue antigens, vol. 79, no. 5, p. 315-325
Publication date2012
Abstract

Pre-formed and de novo anti-human leukocyte antigen (HLA) antibodies induce antibody-mediated rejection and are also involved in mechanisms leading to chronic graft nephropathy. The detection of anti-HLA antibodies by solid-phase assay (SPA) has revolutionized the management of immunized patients before and after kidney transplantation. Characterized by high sensitivity and specificity, the clinical relevance of anti-HLA antibodies by SPA has to be clarified. The presence of donor-specific antibody at the epitope level, their titer, and the use of different crossmatch technologies could help to determine which of the anti-HLA antibodies are friends and which are foes in kidney transplantation. In this review, we summarize the current state of the art on this debated topic, and give clinical guidelines for the management of antibody detection pre- and post-transplantation, based on these evidences and our own clinical expertise.

Keywords
  • Graft Rejection/prevention & control
  • Graft Survival/immunology
  • HLA Antigens/immunology
  • Humans
  • Immunoassay
  • Isoantibodies/analysis/biosynthesis/immunology
  • Kidney Transplantation/immunology
  • Practice Guidelines as Topic
  • Sensitivity and Specificity
Citation (ISO format)
FERRARI-LACRAZ, Sylvie, TIERCY, Jean-Marie, VILLARD, Jean. Detection of anti-HLA antibodies by solid-phase assay in kidney transplantation: friend or foe? In: Tissue antigens, 2012, vol. 79, n° 5, p. 315–325. doi: 10.1111/j.1399-0039.2012.01853.x
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Article (Published version)
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Identifiers
ISSN of the journal0001-2815
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