Potential of T-regulatory cells to protect xenografts

Muller, Yannick; Ehirchiou, Driss; Golshayan, Déla; Buehler, Leo Hans; Seebach, Jorg Dieter

doi:10.1097/MOT.0b013e3283508e17

Scientific article

Review

English

Potential of T-regulatory cells to protect xenografts

ContributorsMuller, Yannick; Ehirchiou, Driss; Golshayan, Déla; Buehler, Leo Hans; Seebach, Jorg Dieter

Published inCurrent opinion in organ transplantation, vol. 17, no. 2, p. 155-161

Publication date2012

Abstract

Immunological barriers still preclude clinical xenotransplantation. The protective role of CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Treg) in allotransplantation is well described and, therefore, could represent a promising therapeutical tool for xenotransplantation. This review addresses the latest findings on Treg in xenotransplantation research.

Keywords

Animals
Antibodies, Monoclonal/immunology/pharmacology
Endothelium, Vascular/immunology
Humans
Immunity, Cellular/drug effects/immunology
Immunosuppressive Agents/pharmacology
Interleukin-10/immunology
Sirolimus/pharmacology
Swine
T-Lymphocytes, Regulatory/drug effects/immunology
Transplantation, Heterologous/immunology

Affiliation

Research group

Citation (ISO format)

MULLER, Yannick et al. Potential of T-regulatory cells to protect xenografts. In: Current opinion in organ transplantation, 2012, vol. 17, n° 2, p. 155–161. doi: 10.1097/MOT.0b013e3283508e17

Article (Published version)

Identifiers

PID : unige:27645
DOI : 10.1097/MOT.0b013e3283508e17
PMID : 22273594

ISSN of the journal1087-2418

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Potential of T-regulatory cells to protect xenografts

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