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Scientific article
Review
English

Potential of T-regulatory cells to protect xenografts

Contributors

Muller, Yannick; Ehirchiou, Driss; Golshayan, Déla; Buehler, Leo Hans; Seebach, Jorg Dieter

Published in

Current opinion in organ transplantation, vol. 17, no. 2, p. 155-161

Publication date

2012

Abstract

Immunological barriers still preclude clinical xenotransplantation. The protective role of CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Treg) in allotransplantation is well described and, therefore, could represent a promising therapeutical tool for xenotransplantation. This review addresses the latest findings on Treg in xenotransplantation research.

Keywords

  • Animals
  • Antibodies, Monoclonal/immunology/pharmacology
  • Endothelium, Vascular/immunology
  • Humans
  • Immunity, Cellular/drug effects/immunology
  • Immunosuppressive Agents/pharmacology
  • Interleukin-10/immunology
  • Sirolimus/pharmacology
  • Swine
  • T-Lymphocytes, Regulatory/drug effects/immunology
  • Transplantation, Heterologous/immunology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MULLER, Yannick et al. Potential of T-regulatory cells to protect xenografts. In: Current opinion in organ transplantation, 2012, vol. 17, n° 2, p. 155–161. doi: 10.1097/MOT.0b013e3283508e17

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1087-2418
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Technical informations

Creation

02/05/2013 08:44:00

First validation

02/05/2013 08:44:00

Update

09/01/2025 10:33:04

Status update

09/01/2025 10:33:04

Last indexation

09/01/2025 10:36:06
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