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Potential of T-regulatory cells to protect xenografts

Golshayan, Déla
Published in Current opinion in organ transplantation. 2012, vol. 17, no. 2, p. 155-61
Abstract Immunological barriers still preclude clinical xenotransplantation. The protective role of CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Treg) in allotransplantation is well described and, therefore, could represent a promising therapeutical tool for xenotransplantation. This review addresses the latest findings on Treg in xenotransplantation research.
Keywords AnimalsAntibodies, Monoclonal/immunology/pharmacologyEndothelium, Vascular/immunologyHumansImmunity, Cellular/drug effects/immunologyImmunosuppressive Agents/pharmacologyInterleukin-10/immunologySirolimus/pharmacologySwineT-Lymphocytes, Regulatory/drug effects/immunologyTransplantation, Heterologous/immunology
PMID: 22273594
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Article (Published version) (440 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Cultures cellulaires et transplantations (519)
Laboratoire d'immunologie translationnelle (856)
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MULLER, Yannick et al. Potential of T-regulatory cells to protect xenografts. In: Current opinion in organ transplantation, 2012, vol. 17, n° 2, p. 155-61. doi: 10.1097/MOT.0b013e3283508e17 https://archive-ouverte.unige.ch/unige:27645

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Deposited on : 2013-05-02

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