Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

Gottenberg, Jacques-Eric; Dayer, Jean-Michel; Lukas, Cedric; Ducot, Beatrice; Chiocchia, Gilles; Cantagrel, Alain; Saraux, Alain; Roux-Lombard, Pascale; Mariette, Xavier

doi:10.1136/annrheumdis-2011-200975

Scientific article

English

Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

ContributorsGottenberg, Jacques-Eric; Dayer, Jean-Michel; Lukas, Cedric; Ducot, Beatrice; Chiocchia, Gilles; Cantagrel, Alain; Saraux, Alain; Roux-Lombard, Pascale; Mariette, Xavier

Published inAnnals of the rheumatic diseases, vol. 71, no. 7, p. 1243-1248

Publication date2012

Abstract

To identify a specific pattern of serum cytokines that correlates with the diagnosis, activity and severity of rheumatoid arthritis (RA) in patients with early RA as well as with the level of serum markers of B cell activation.

Keywords

Adult
Arthritis, Rheumatoid/blood/diagnosis/immunology
B-Lymphocytes/immunology/metabolism/pathology
Biological Markers/blood
Early Diagnosis
Female
Humans
Hyperalgesia/pathology/physiopathology
Interleukin-6/blood
Interleukins/blood
Joints/pathology/physiopathology
Lymphocyte Activation
Male
Middle Aged
Outcome Assessment (Health Care)
Prospective Studies

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)

Citation (ISO format)

GOTTENBERG, Jacques-Eric et al. Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort. In: Annals of the rheumatic diseases, 2012, vol. 71, n° 7, p. 1243–1248. doi: 10.1136/annrheumdis-2011-200975

Article (Published version)

Identifiers

PID : unige:27588
DOI : 10.1136/annrheumdis-2011-200975
PMID : 22532637

Journal ISSN0003-4967

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Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

To identify a specific pattern of serum cytokines that correlates with the diagnosis, activity and severity of rheumatoid arthritis (RA) in patients with early RA as well as with the level of serum markers of B cell activation.

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