Autoantibodies against apolipoprotein A-1 and phosphorylcholine for diagnosis of non-ST-segment elevation myocardial infarction

Keller, P.-F.; Pagano, Sabrina; Roux-Lombard, Pascale; Sigaud, Martine Patricia Marie; Rutschmann, Ophélie; Mach, François; Hochstrasser, Denis; Vuilleumier, Nicolas

doi:10.1111/j.1365-2796.2011.02479.x

Scientific article

English

Autoantibodies against apolipoprotein A-1 and phosphorylcholine for diagnosis of non-ST-segment elevation myocardial infarction

ContributorsKeller, P.-F.; Pagano, Sabrina

; Roux-Lombard, Pascale; Sigaud, Martine Patricia Marie; Rutschmann, Ophélie; Mach, François; Hochstrasser, Denis; Vuilleumier, Nicolas

Published inJournal of internal medicine, vol. 271, no. 5, p. 451-462

Publication date2012

Abstract

To explore the diagnostic accuracies of anti-apolipoproteinA-1 (anti-ApoA-1) IgG and anti-phosphorylcholine (anti-PC) IgM alone, expressed as a ratio (anti-ApoA-1 IgG/anti-PC IgM), and combined with the Thrombolysis In Myocardial Infarction (TIMI) score for non-ST-segment elevation myocardial infarction (NSTEMI) (NSTEMI-TIMI score) to create a new diagnostic algorithm - the Clinical Autoantibody Ratio (CABR) score - for the diagnosis of NSTEMI and subsequent cardiac troponin I (cTnI) elevation in patients with acute chest pain (ACP).

Keywords

Aged
Algorithms
Apolipoprotein A-I/immunology
Area Under Curve
Autoantibodies/blood
Confidence Intervals
Electrocardiography/methods
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G/blood
Immunoglobulin M/blood
Male
Middle Aged
Myocardial Infarction/diagnosis/drug therapy/immunology
Odds Ratio
Phosphorylcholine/immunology
Predictive Value of Tests
Thrombolytic Therapy/methods

Affiliation entities

Research groups

Citation (ISO format)

KELLER, P.-F. et al. Autoantibodies against apolipoprotein A-1 and phosphorylcholine for diagnosis of non-ST-segment elevation myocardial infarction. In: Journal of internal medicine, 2012, vol. 271, n° 5, p. 451–462. doi: 10.1111/j.1365-2796.2011.02479.x

Article (Published version)

Identifiers

PID : unige:27584
DOI : 10.1111/j.1365-2796.2011.02479.x
PMID : 22061093

Journal ISSN0954-6820

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Autoantibodies against apolipoprotein A-1 and phosphorylcholine for diagnosis of non-ST-segment elevation myocardial infarction

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