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Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial

Borel, Jean-Christian
Tamisier, Renaud
Gonzalez-Bermejo, Jesus
Baguet, Jean-Philippe
Monneret, Denis
Wuyam, Bernard
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Published in Chest. 2012, vol. 141, no. 3, p. 692-702
Abstract Open studies suggest that treatment of obesity hypoventilation syndrome (OHS) by noninvasive ventilation (NIV) restores sleep quality and daytime vigilance and reduces cardiovascular morbidity. However, to our knowledge no randomized controlled trial (RCT) comparing NIV to conservative measures is available in the field. The goal of this study was to assess in patients with OHS, during an RCT, effects of 1-month NIV compared with lifestyle counseling on blood gas measurements, sleep quality, vigilance, and cardiovascular, metabolic, and inflammatory parameters.
Keywords AgedBlood Gas AnalysisBlood Pressure/physiologyFemaleGlucose/metabolismHumansLife StyleLipid Metabolism/physiologyMaleMiddle AgedObesity Hypoventilation Syndrome/blood/physiopathology/therapyPatient CompliancePositive-Pressure RespirationSleep/physiologyTreatment Outcome
PMID: 21885724
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Research group Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
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BOREL, Jean-Christian et al. Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial. In: Chest, 2012, vol. 141, n° 3, p. 692-702. https://archive-ouverte.unige.ch/unige:27580

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Deposited on : 2013-04-26

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