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Scientific article
English

Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial

Published inChest, vol. 141, no. 3, p. 692-702
Publication date2012
Abstract

Open studies suggest that treatment of obesity hypoventilation syndrome (OHS) by noninvasive ventilation (NIV) restores sleep quality and daytime vigilance and reduces cardiovascular morbidity. However, to our knowledge no randomized controlled trial (RCT) comparing NIV to conservative measures is available in the field. The goal of this study was to assess in patients with OHS, during an RCT, effects of 1-month NIV compared with lifestyle counseling on blood gas measurements, sleep quality, vigilance, and cardiovascular, metabolic, and inflammatory parameters.

Keywords
  • Aged
  • Blood Gas Analysis
  • Blood Pressure/physiology
  • Female
  • Glucose/metabolism
  • Humans
  • Life Style
  • Lipid Metabolism/physiology
  • Male
  • Middle Aged
  • Obesity Hypoventilation Syndrome/blood/physiopathology/therapy
  • Patient Compliance
  • Positive-Pressure Respiration
  • Sleep/physiology
  • Treatment Outcome
Citation (ISO format)
BOREL, Jean-Christian et al. Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial. In: Chest, 2012, vol. 141, n° 3, p. 692–702. doi: 10.1378/chest.10-2531
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Article (Published version)
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ISSN of the journal0012-3692
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