Scientific article
Open access

NOX enzymes: potential target for the treatment of acute lung injury

Published inCellular and molecular life sciences, vol. 69, no. 14, p. 2373-2385
  • Open Access - Licence nationale Springer
Publication date2012

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), is characterized by acute inflammation, disruption of the alveolar-capillary barrier, and in the organizing stage by alveolar pneumocytes hyperplasia and extensive lung fibrosis. The cellular and molecular mechanisms leading to the development of ALI/ARDS are not completely understood, but there is evidence that reactive oxygen species (ROS) generated by inflammatory cells as well as epithelial and endothelial cells are responsible for inflammatory response, lung damage, and abnormal repair. Among all ROS-producing enzymes, the members of NADPH oxidases (NOXs), which are widely expressed in different lung cell types, have been shown to participate in cellular processes involved in the maintenance of lung integrity. It is not surprising that change in NOXs' expression and function is involved in the development of ALI/ARDS. In this context, the use of NOX inhibitors could be a possible therapeutic perspective in the management of this syndrome. In this article, we summarize the current knowledge concerning some cellular aspects of NOXs localization and function in the lungs, consider their contribution in the development of ALI/ARDS and discuss the place of NOX inhibitors as potential therapeutical target.

  • Acute Lung Injury/enzymology/pathology/therapy
  • Cytokines/metabolism
  • Enzyme Inhibitors/therapeutic use
  • Humans
  • NADPH Oxidase/antagonists & inhibitors/metabolism
  • Protein Isoforms/antagonists & inhibitors/metabolism
  • Respiratory Distress Syndrome, Adult/enzymology/pathology/therapy
Citation (ISO format)
CARNESECCHI, Stéphanie, PACHE, Jean-Claude, BARAZZONE, Constance. NOX enzymes: potential target for the treatment of acute lung injury. In: Cellular and molecular life sciences, 2012, vol. 69, n° 14, p. 2373–2385. doi: 10.1007/s00018-012-1013-6
Main files (1)
Article (Published version)
ISSN of the journal1420-682X

Technical informations

Creation03/26/2013 3:54:00 PM
First validation03/26/2013 3:54:00 PM
Update time03/14/2023 8:09:24 PM
Status update03/14/2023 8:09:24 PM
Last indexation08/29/2023 6:14:38 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack