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NOX enzymes: potential target for the treatment of acute lung injury

Published in Cellular and molecular life sciences. 2012, vol. 69, no. 14, p. 2373-85
Collection Open Access - Licence nationale Springer
Abstract Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), is characterized by acute inflammation, disruption of the alveolar-capillary barrier, and in the organizing stage by alveolar pneumocytes hyperplasia and extensive lung fibrosis. The cellular and molecular mechanisms leading to the development of ALI/ARDS are not completely understood, but there is evidence that reactive oxygen species (ROS) generated by inflammatory cells as well as epithelial and endothelial cells are responsible for inflammatory response, lung damage, and abnormal repair. Among all ROS-producing enzymes, the members of NADPH oxidases (NOXs), which are widely expressed in different lung cell types, have been shown to participate in cellular processes involved in the maintenance of lung integrity. It is not surprising that change in NOXs' expression and function is involved in the development of ALI/ARDS. In this context, the use of NOX inhibitors could be a possible therapeutic perspective in the management of this syndrome. In this article, we summarize the current knowledge concerning some cellular aspects of NOXs localization and function in the lungs, consider their contribution in the development of ALI/ARDS and discuss the place of NOX inhibitors as potential therapeutical target.
Keywords Acute Lung Injury/enzymology/pathology/therapyCytokines/metabolismEnzyme Inhibitors/therapeutic useHumansNADPH Oxidase/antagonists & inhibitors/metabolismProtein Isoforms/antagonists & inhibitors/metabolismRespiratory Distress Syndrome, Adult/enzymology/pathology/therapy
PMID: 22581364
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Article (Published version) (432 Kb) - public document Free access
Research groups Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
Groupe Pache Jean-Claude (pathologie clinique) (658)
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CARNESECCHI, Stéphanie, PACHE, Jean-Claude, BARAZZONE, Constance. NOX enzymes: potential target for the treatment of acute lung injury. In: Cellular and molecular life sciences, 2012, vol. 69, n° 14, p. 2373-85. doi: 10.1007/s00018-012-1013-6 https://archive-ouverte.unige.ch/unige:27577

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Deposited on : 2013-04-26

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