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Scientific article
English

Riedel's thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease?

Published inThyroid, vol. 22, no. 9, p. 964-968
Publication date2012
Abstract

Riedel's thyroiditis (RT) is a very rare chronic fibrosing disorder of unknown etiology that is often associated with multifocal fibrosclerosis (MFS). Immunoglobulin (Ig) G4-related sclerosing disease (IgG4-RSD), a new clinico-pathological entity also associated with MFS, is characterized by IgG4+ plasma cell infiltration and fibrosis in one or more organs. Although the association of RT and IgG4-RSD has been suggested, it has seldom been studied or reported. We report a classical case of RT with serological (IgG4 levels) and immunohistochemical (IgG and IgG4) assessment, in search of an underlying IgG4-RSD.

Keywords
  • Chronic Disease
  • Eosinophils/pathology
  • Female
  • Goiter, Nodular/surgery
  • Humans
  • Immunoglobulin G/analysis/metabolism
  • Immunohistochemistry
  • Lymphocytes/pathology
  • Middle Aged
  • Plasma Cells/pathology
  • Sclerosis/diagnosis/pathology
  • Sensitivity and Specificity
  • Thyroidectomy/methods
  • Thyroiditis/diagnosis/pathology
Citation (ISO format)
PUSZTASZERI, Marc et al. Riedel’s thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease? In: Thyroid, 2012, vol. 22, n° 9, p. 964–968. doi: 10.1089/thy.2011.0404
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Article (Published version)
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ISSN of the journal1050-7256
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