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Title

Riedel's thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease?

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Published in Thyroid. 2012, vol. 22, no. 9, p. 964-8
Abstract Riedel's thyroiditis (RT) is a very rare chronic fibrosing disorder of unknown etiology that is often associated with multifocal fibrosclerosis (MFS). Immunoglobulin (Ig) G4-related sclerosing disease (IgG4-RSD), a new clinico-pathological entity also associated with MFS, is characterized by IgG4+ plasma cell infiltration and fibrosis in one or more organs. Although the association of RT and IgG4-RSD has been suggested, it has seldom been studied or reported. We report a classical case of RT with serological (IgG4 levels) and immunohistochemical (IgG and IgG4) assessment, in search of an underlying IgG4-RSD.
Keywords Chronic DiseaseEosinophils/pathologyFemaleGoiter, Nodular/surgeryHumansImmunoglobulin G/analysis/metabolismImmunohistochemistryLymphocytes/pathologyMiddle AgedPlasma Cells/pathologySclerosis/diagnosis/pathologySensitivity and SpecificityThyroidectomy/methodsThyroiditis/diagnosis/pathology
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PMID: 22827716
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Structures
Research groups Chirurgie thoracique et chirurgie endocrinologique (573)
Groupe Pache Jean-Claude (pathologie clinique) (658)
Mésothéliome pleural malin (944)
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PUSZTASZERI, Marc et al. Riedel's thyroiditis with increased IgG4 plasma cells: evidence for an underlying IgG4-related sclerosing disease?. In: Thyroid, 2012, vol. 22, n° 9, p. 964-8. https://archive-ouverte.unige.ch/unige:27576

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Deposited on : 2013-04-26

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