The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients

Baur, Katharina; Mertens, Joachim C; Schmitt, Johannes; Iwata, Rika; Stieger, Bruno; Frei, Pascal; Seifert, Burkhardt; Bischoff Ferrari, Heike A; von Eckardstein, Arnold; Müllhaupt, Beat; Geier, Andreas; Negro, Francesco; Rubbia-Brandt, Laura

doi:10.3851/IMP2018

Scientific article

English

The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients

ContributorsBaur, Katharina; Mertens, Joachim C; Schmitt, Johannes; Iwata, Rika; Stieger, Bruno; Frei, Pascal; Seifert, Burkhardt; Bischoff Ferrari, Heike A; von Eckardstein, Arnold; Müllhaupt, Beat; Geier, Andreas; Negro, Francesco; Rubbia-Brandt, Laura

Published inAntiviral therapy, vol. 17, no. 3, p. 541-547

Publication date2012

Abstract

Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor (NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients.

Keywords

Adult
Aged
Antiviral Agents/therapeutic use
Cohort Studies
Drug Therapy, Combination
Female
Genotype
Haplotypes/genetics
Hepacivirus/drug effects/genetics
Hepatitis C, Chronic/drug therapy/genetics/virology
Humans
Interferons/therapeutic use
Male
Middle Aged
Polyethylene Glycols/therapeutic use
Polymorphism, Genetic
Receptors, Calcitriol/genetics
Ribavirin/therapeutic use
Treatment Outcome
Vitamin D/blood

Affiliation

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research group

Citation (ISO format)

BAUR, Katharina et al. The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients. In: Antiviral therapy, 2012, vol. 17, n° 3, p. 541–547. doi: 10.3851/IMP2018

Article (Published version)

Identifiers

PID : unige:27573
DOI : 10.3851/IMP2018
PMID : 22300961

Commercial URLhttp://www.intmedpress.com/journals/avt/abstract.cfm?id=2018&pid=48

ISSN of the journal1359-6535

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The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients

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