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Title

The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients

Authors
Baur, Katharina
Mertens, Joachim C
Schmitt, Johannes
Iwata, Rika
Stieger, Bruno
Seifert, Burkhardt
Bischoff Ferrari, Heike A
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Published in Antiviral Therapy. 2012, vol. 17, no. 3, p. 541-7
Abstract Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor (NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients.
Keywords AdultAgedAntiviral Agents/therapeutic useCohort StudiesDrug Therapy, CombinationFemaleGenotypeHaplotypes/geneticsHepacivirus/drug effects/geneticsHepatitis C, Chronic/drug therapy/genetics/virologyHumansInterferons/therapeutic useMaleMiddle AgedPolyethylene Glycols/therapeutic usePolymorphism, GeneticReceptors, Calcitriol/geneticsRibavirin/therapeutic useTreatment OutcomeVitamin D/blood
Identifiers
PMID: 22300961
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Research groups Métastases du foie (657)
Etudes et traitement de l'hépatite C et B (554)
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(ISO format)
BAUR, Katharina et al. The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients. In: Antiviral Therapy, 2012, vol. 17, n° 3, p. 541-7. https://archive-ouverte.unige.ch/unige:27573

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Deposited on : 2013-04-26

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