The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients

Baur, Katharina; Mertens, Joachim C; Schmitt, Johannes; Iwata, Rika; Stieger, Bruno; Frei, Pascal; Seifert, Burkhardt; Bischoff Ferrari, Heike A; von Eckardstein, Arnold; Müllhaupt, Beat; Geier, Andreas; Negro, Francesco; Rubbia-Brandt, Laura

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Title		The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients
Authors		Baur, Katharina Mertens, Joachim C Schmitt, Johannes Iwata, Rika Stieger, Bruno Frei, Pascal Seifert, Burkhardt Bischoff Ferrari, Heike A von Eckardstein, Arnold Müllhaupt, Beat Geier, Andreas Negro, Francesco Rubbia-Brandt, Laura show all authors [1 - 13]
Published in		Antiviral Therapy. 2012, vol. 17, no. 3, p. 541-7
Abstract		Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor (NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients.
Keywords		Adult — Aged — Antiviral Agents/therapeutic use — Cohort Studies — Drug Therapy, Combination — Female — Genotype — Haplotypes/genetics — Hepacivirus/drug effects/genetics — Hepatitis C, Chronic/drug therapy/genetics/virology — Humans — Interferons/therapeutic use — Male — Middle Aged — Polyethylene Glycols/therapeutic use — Polymorphism, Genetic — Receptors, Calcitriol/genetics — Ribavirin/therapeutic use — Treatment Outcome — Vitamin D/blood
Identifiers		DOI: 10.3851/IMP2018 PMID: 22300961
Full text		Article (Published version) (327 Kb) - Limited access to UNIGE Other version: http://www.intmedpress.com/journals/avt/abstract.cfm?id=2018&pid=48
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups		Métastases du foie (657) Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		BAUR, Katharina et al. The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients. In: Antiviral Therapy, 2012, vol. 17, n° 3, p. 541-7. https://archive-ouverte.unige.ch/unige:27573