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Title

The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy

Authors
Weber, Damien C
Laouiti, Mahomet
Granger, Perrine
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Published in Radiation Oncology. 2012, vol. 7, p. 66
Abstract Androgens stimulate the production of hypoxia-inducible factor (HIF1α) and ultimately vascular endothelial growth factor (VEGF-A). Additionally, epithelial growth factor (EGF) mediates HIF1α production. Carbonic anhydrase IX (CAIX) expression is associated with tumor cell hypoxia in a variety of malignancies. This study assesses the prognostic relation between HIF1α, VEGF-A, EGF Receptor and CAIX expression by immunochemistry in diagnostic samples of patients with intermediate- and high-risk localized prostate cancer treated with radiation therapy, with or without androgen deprivation therapy (ADT).
Keywords AgedAged, 80 and overAndrogen Antagonists/therapeutic useDisease-Free SurvivalHumansHypoxia-Inducible Factor 1, alpha Subunit/biosynthesisImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedNeoplasm GradingPrognosisProportional Hazards ModelsProstatic Neoplasms/metabolism/mortality/therapyRadiotherapyReceptor, Epidermal Growth Factor/biosynthesisRisk FactorsTumor Markers, Biological/analysisVascular Endothelial Growth Factor A/biosynthesis
Identifiers
PMID: 22546016
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Article (Published version) (212 Kb) - public document Free access
Structures
Research groups Métastases du foie (657)
Epidémiologie clinique (115)
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WEBER, Damien C et al. The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy. In: Radiation Oncology, 2012, vol. 7, p. 66. https://archive-ouverte.unige.ch/unige:27569

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Deposited on : 2013-04-25

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