Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome

Fattovich, Giovanna; Baroni, Gianluca Svegliati; Pasino, Michela; Pierantonelli, Irene; Covolo, Loredana; Ieluzzi, Donatella; Passigato, Nicola; Tonon, Angelo; Faraci, Maria Grazia; Guido, Maria; Negro, Francesco

doi:10.1016/j.dld.2011.12.006

Scientific article

English

Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome

ContributorsFattovich, Giovanna; Baroni, Gianluca Svegliati; Pasino, Michela; Pierantonelli, Irene; Covolo, Loredana; Ieluzzi, Donatella; Passigato, Nicola; Tonon, Angelo; Faraci, Maria Grazia; Guido, Maria; Negro, Francesco

Published inDigestive and Liver Disease, vol. 44, no. 5, p. 419-425

Publication date2012

Abstract

The role of insulin resistance in predicting virological response to therapy of chronic hepatitis C is debated. We assessed the association between basal (defined as homeostasis model assessment of insulin resistance (HOMA-IR)>2) and post-load insulin resistance (as oral glucose insulin sensitivity index<9.8 mg/kg/min) with the rapid and sustained virological responses in chronic hepatitis C.

Keywords

Antiviral Agents/therapeutic use
Blood Glucose/analysis
Female
Ferritins/blood
Genotype
Hepacivirus/genetics
Hepatitis C, Chronic/drug therapy/virology
Humans
Insulin Resistance
Interferon-alpha/therapeutic use
Male
Middle Aged
Polyethylene Glycols/therapeutic use
Prospective Studies
RNA/metabolism
Recombinant Proteins/therapeutic use
Ribavirin/therapeutic use

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Etudes et traitement de l'hépatite C et B (554)

Citation (ISO format)

FATTOVICH, Giovanna et al. Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome. In: Digestive and Liver Disease, 2012, vol. 44, n° 5, p. 419–425. doi: 10.1016/j.dld.2011.12.006

Article (Published version)

Identifiers

PID : unige:27536
DOI : 10.1016/j.dld.2011.12.006
PMID : 22277808

Journal ISSN1590-8658

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Post-load insulin resistance does not predict virological response to treatment of chronic hepatitis C patients without the metabolic syndrome

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