UNIGE document Scientific Article
previous document  unige:27534  next document
add to browser collection
Title

The interaction of metabolic factors with HCV infection: does it matter?

Authors
Bugianesi, Elisabetta
Salamone, Federico
Published in Journal of Hepatology. 2012, vol. 56 Suppl 1, p. S56-65
Abstract Given the pandemic spread of the hepatitis C virus (HCV) infection and the metabolic syndrome (MS), the burden of their interaction is a major public health issue, bound to increase in the near term. A better appreciation of the clinical consequences of the relationship between HCV and MS is needed, not only due to their potential synergism on liver disease severity, but also because of the multifaceted interactions between HCV and glucose and lipid metabolism. HCV infection per se does not carry an increased risk of MS, but is able to perturb glucose homeostasis through several direct and indirect mechanisms, leading to both hepatic and extrahepatic insulin resistance. This translates into accelerated liver disease progression (including the development of hepatocellular carcinoma), reduced response to antivirals and, in susceptible individuals, increased risk of developing full-blown type 2 diabetes. HCV may also cause hepatic steatosis, especially in patients infected with genotype 3, although the clinical impact of viral steatosis is debated. Possibly as a result of HCV-induced insulin resistance, and despite a paradoxically favourable lipid profile, the cardiovascular risk is moderately increased in chronic hepatitis C. In addition, the interaction with the MS further increases the risks of cirrhosis, hepatocellular carcinoma, diabetes, and cardiovascular events. Thus, targeted lifestyle and pharmacological measures are urgently warranted in chronic hepatitis C with metabolic alterations.
Keywords Cardiovascular Diseases/etiology/mortalityDiabetes Mellitus, Type 2/complicationsDisease ProgressionFatty Liver/etiologyHepatitis C, Chronic/complicationsHumansInsulin ResistanceLiver Cirrhosis/etiologyMetabolic Syndrome X/complications
Identifiers
PMID: 22300466
Note 554
Full text
Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Etudes et traitement de l'hépatite C et B (554)
Citation
(ISO format)
BUGIANESI, Elisabetta, SALAMONE, Federico, NEGRO, Francesco. The interaction of metabolic factors with HCV infection: does it matter?. In: Journal of Hepatology, 2012, vol. 56 Suppl 1, p. S56-65. https://archive-ouverte.unige.ch/unige:27534

165 hits

1 download

Update

Deposited on : 2013-04-24

Export document
Format :
Citation style :