Creation of Highly Congested Quaternary Centers via Cu-catalyzed Conjugate Addition of Alkenyl Alanates to β-Substituted Cyclic Enones

Mueller, Daniel; Alexakis, Alexandre

doi:10.1021/ol400378v

Scientific article

English

Creation of Highly Congested Quaternary Centers via Cu-catalyzed Conjugate Addition of Alkenyl Alanates to β-Substituted Cyclic Enones

ContributorsMueller, Daniel; Alexakis, Alexandre

Published inOrganic letters, vol. 15, no. 7, p. 1594-1597

Publication date2013

Abstract

Easily prepared alkenylalanates proved to be excellent nucleophiles for the creation of highly congested quaternary centers via copper-catalyzed conjugate addition. In addition, functionalized cis-decaline systems can now be prepared in a simple two-step sequence involving Cu-catalyzed conjugate addition with functionalized alkenylalanates.

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

MUELLER, Daniel, ALEXAKIS, Alexandre. Creation of Highly Congested Quaternary Centers via Cu-catalyzed Conjugate Addition of Alkenyl Alanates to β-Substituted Cyclic Enones. In: Organic letters, 2013, vol. 15, n° 7, p. 1594–1597. doi: 10.1021/ol400378v

Article (Published version)

Identifiers

PID : unige:27319
DOI : 10.1021/ol400378v

ISSN of the journal1523-7052

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Creation of Highly Congested Quaternary Centers via Cu-catalyzed Conjugate Addition of Alkenyl Alanates to β-Substituted Cyclic Enones

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