A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.

Lange, Christian M; Bibert, Stéphanie; Kutalik, Zoltan; Burgisser, Philippe; Cerny, Andreas; Dufour, Jean-François Jacques; Geier, Andreas; Gerlach, Tilman Joern; Heim, Markus H; Malinverni, Raffaele; Negro, Francesco; Regenass, Stephan; Badenhoop, Klaus; Bojunga, Jörg; Sarrazin, Christoph; Zeuzem, Stefan; Müller, Tobias; Berg, Thomas; Bochud, Pierre-Yves; Moradpour, Darius

doi:10.1371/journal.pone.0040159

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Title		A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.
Authors		Lange, Christian M Bibert, Stéphanie Kutalik, Zoltan Burgisser, Philippe Cerny, Andreas Dufour, Jean-François Jacques Geier, Andreas Gerlach, Tilman Joern Heim, Markus H Malinverni, Raffaele Negro, Francesco Regenass, Stephan Badenhoop, Klaus Bojunga, Jörg Sarrazin, Christoph Zeuzem, Stefan Müller, Tobias Berg, Thomas Bochud, Pierre-Yves Moradpour, Darius show all authors [1 - 20]
Published in		PloS one. 2012, vol. 7, no. 7, e40159
Abstract		To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Keywords		25-Hydroxyvitamin D3 1-alpha-Hydroxylase/genetics — Adult — Aged — Calcifediol/blood — Demography — Female — Gene Frequency/genetics — Hepatitis C, Chronic/blood/drug therapy/genetics/virology — Humans — Interferon-alpha/therapeutic use — Interleukins/genetics — Male — Middle Aged — Polymorphism, Single Nucleotide/genetics — Reproducibility of Results — Ribavirin/therapeutic use — Seasons — Treatment Outcome — Vitamin D/blood/metabolism — Young Adult
Identifiers		DOI: 10.1371/journal.pone.0040159 PMID: 22808108
Full text		Article (Published version) (153 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		LANGE, Christian M et al. A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C. In: PloS one, 2012, vol. 7, n° 7, p. e40159. doi: 10.1371/journal.pone.0040159 https://archive-ouverte.unige.ch/unige:27166