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Title

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection

Authors
Patin, Etienne
Kutalik, Zoltán
Guergnon, Julien
Nalpas, Bertrand
Jouanguy, Emmanuelle
Munteanu, Mona
Bousquet, Laurence
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Published in Gastroenterology. 2012, vol. 143, no. 5, p. 1244-52.e1-12
Abstract Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection.
Keywords AdultApoptosis/geneticsDisease ProgressionEye Proteins/geneticsFemaleGenome-Wide Association StudyGenotypeHepacivirusHepatitis C, Chronic/complications/virologyHumansLipase/geneticsLiver Cirrhosis/genetics/virologyLogistic ModelsMaleMembrane Proteins/geneticsPhenotypePolymorphism, Single NucleotideProportional Hazards ModelsProto-Oncogene Proteins/geneticsReceptor Protein-Tyrosine Kinases/geneticsUbiquitin-Protein Ligases/geneticsYoung Adult
Identifiers
PMID: 22841784
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Research group Etudes et traitement de l'hépatite C et B (554)
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PATIN, Etienne et al. Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. In: Gastroenterology, 2012, vol. 143, n° 5, p. 1244-52.e1-12. https://archive-ouverte.unige.ch/unige:27165

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Deposited on : 2013-04-03

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