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Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection |
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Published in | Gastroenterology. 2012, vol. 143, no. 5, p. 1244-52.e1-12 | |
Abstract | Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection. | |
Keywords | Adult — Apoptosis/genetics — Disease Progression — Eye Proteins/genetics — Female — Genome-Wide Association Study — Genotype — Hepacivirus — Hepatitis C, Chronic/complications/virology — Humans — Lipase/genetics — Liver Cirrhosis/genetics/virology — Logistic Models — Male — Membrane Proteins/genetics — Phenotype — Polymorphism, Single Nucleotide — Proportional Hazards Models — Proto-Oncogene Proteins/genetics — Receptor Protein-Tyrosine Kinases/genetics — Ubiquitin-Protein Ligases/genetics — Young Adult | |
Identifiers | PMID: 22841784 | |
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Research group | Etudes et traitement de l'hépatite C et B (554) | |
Citation (ISO format) | PATIN, Etienne et al. Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. In: Gastroenterology, 2012, vol. 143, n° 5, p. 1244-52.e1-12. doi: 10.1053/j.gastro.2012.07.097 https://archive-ouverte.unige.ch/unige:27165 |