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Scientific article
English

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection

Published inGastroenterology, vol. 143, no. 5, p. 1244-1252.e1-12
Publication date2012
Abstract

Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection.

Keywords
  • Adult
  • Apoptosis/genetics
  • Disease Progression
  • Eye Proteins/genetics
  • Female
  • Genome-Wide Association Study
  • Genotype
  • Hepacivirus
  • Hepatitis C, Chronic/complications/virology
  • Humans
  • Lipase/genetics
  • Liver Cirrhosis/genetics/virology
  • Logistic Models
  • Male
  • Membrane Proteins/genetics
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Proportional Hazards Models
  • Proto-Oncogene Proteins/genetics
  • Receptor Protein-Tyrosine Kinases/genetics
  • Ubiquitin-Protein Ligases/genetics
  • Young Adult
Citation (ISO format)
PATIN, Etienne et al. Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. In: Gastroenterology, 2012, vol. 143, n° 5, p. 1244–1252.e1–12. doi: 10.1053/j.gastro.2012.07.097
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0016-5085
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