Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection

Patin, Etienne; Kutalik, Zoltán; Guergnon, Julien; Bibert, Stéphanie; Nalpas, Bertrand; Jouanguy, Emmanuelle; Munteanu, Mona; Bousquet, Laurence; Argiro, Laurent; Halfon, Philippe; Boland, Anne; Müllhaupt, Beat; Semela, David; Dufour, Jean-François Jacques; Heim, Markus H; Moradpour, Darius; Cerny, Andreas; Malinverni, Raffaele; Hirsch, Hans; Martinetti, Gladys; Suppiah, Vijayaprakash; Stewart, Graeme; Booth, David R; George, Jacob; Casanova, Jean-Laurent; Bréchot, Christian; Rice, Charles M; Talal, Andrew H; Jacobson, Ira M; Bourlière, Marc; Theodorou, Ioannis; Poynard, Thierry; Negro, Francesco; Pol, Stanislas; Bochud, Pierre-Yves; Abel, Laurent

doi:10.1053/j.gastro.2012.07.097

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Title		Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection
Authors		Patin, Etienne Kutalik, Zoltán Guergnon, Julien Bibert, Stéphanie Nalpas, Bertrand Jouanguy, Emmanuelle Munteanu, Mona Bousquet, Laurence Argiro, Laurent Halfon, Philippe Boland, Anne Müllhaupt, Beat Semela, David Dufour, Jean-François Jacques Heim, Markus H Moradpour, Darius Cerny, Andreas Malinverni, Raffaele Hirsch, Hans Martinetti, Gladys Suppiah, Vijayaprakash Stewart, Graeme Booth, David R George, Jacob Casanova, Jean-Laurent Bréchot, Christian Rice, Charles M Talal, Andrew H Jacobson, Ira M Bourlière, Marc Theodorou, Ioannis Poynard, Thierry Negro, Francesco Pol, Stanislas Bochud, Pierre-Yves Abel, Laurent show all authors [1 - 36]
Published in		Gastroenterology. 2012, vol. 143, no. 5, p. 1244-52.e1-12
Abstract		Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection.
Keywords		Adult — Apoptosis/genetics — Disease Progression — Eye Proteins/genetics — Female — Genome-Wide Association Study — Genotype — Hepacivirus — Hepatitis C, Chronic/complications/virology — Humans — Lipase/genetics — Liver Cirrhosis/genetics/virology — Logistic Models — Male — Membrane Proteins/genetics — Phenotype — Polymorphism, Single Nucleotide — Proportional Hazards Models — Proto-Oncogene Proteins/genetics — Receptor Protein-Tyrosine Kinases/genetics — Ubiquitin-Protein Ligases/genetics — Young Adult
Identifiers		DOI: 10.1053/j.gastro.2012.07.097 PMID: 22841784
Full text		Article (Published version) (2.8 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Etudes et traitement de l'hépatite C et B (554)
Citation (ISO format)		PATIN, Etienne et al. Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. In: Gastroenterology, 2012, vol. 143, n° 5, p. 1244-52.e1-12. doi: 10.1053/j.gastro.2012.07.097 https://archive-ouverte.unige.ch/unige:27165