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Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia |
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Published in | Critical care medicine. 2004, vol. 32, no. 8, p. 1759-63 | |
Abstract | Infection of pancreatic necrosis is a severe complication of acute pancreatitis. Because Toll-like receptor 4 (TLR4) has been identified as a receptor necessary to transduct the signal of bacteria-derived lipopolysaccharide into cells, we investigated the role of TLR4 on pancreatic and pulmonary injury in acute pancreatitis and acute pancreatitis associated with endotoxemia in wild-type and TLR4-deficient mice. | |
Keywords | Acute Disease — Amylases/blood/secretion — Animals — Caerulein — Disease Models, Animal — Lipopolysaccharides — Lung Diseases/chemically induced/etiology/metabolism — Membrane Glycoproteins/metabolism — Mice — Pancreas/enzymology — Pancreatitis/chemically induced/complications/metabolism — Receptors, Cell Surface/metabolism — Toll-Like Receptor 4 — Toll-Like Receptors | |
Identifiers | PMID: 15286555 | |
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Research groups | Mucoviscidose et jonctions GAP (229) Pharmacologie et imagerie du foie (664) Physiopathologie de la pancréatite aiguë (601) | |
Citation (ISO format) | PASTOR, Catherine et al. Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. In: Critical care medicine, 2004, vol. 32, n° 8, p. 1759-63. https://archive-ouverte.unige.ch/unige:27046 |