Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia

Pastor, Catherine; Pugin, Jérôme; Kwak, Brenda; Chanson, Marc; Mach, François; Hadengue, Antoine; Frossard, Jean-Louis

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Title		Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia
Authors		Pastor, Catherine Pugin, Jérôme Kwak, Brenda Chanson, Marc Mach, François Hadengue, Antoine Frossard, Jean-Louis
Published in		Critical Care Medicine. 2004, vol. 32, no. 8, p. 1759-63
Abstract		Infection of pancreatic necrosis is a severe complication of acute pancreatitis. Because Toll-like receptor 4 (TLR4) has been identified as a receptor necessary to transduct the signal of bacteria-derived lipopolysaccharide into cells, we investigated the role of TLR4 on pancreatic and pulmonary injury in acute pancreatitis and acute pancreatitis associated with endotoxemia in wild-type and TLR4-deficient mice.
Keywords		Acute Disease — Amylases/blood/secretion — Animals — Caerulein — Disease Models, Animal — Lipopolysaccharides — Lung Diseases/chemically induced/etiology/metabolism — Membrane Glycoproteins/metabolism — Mice — Pancreas/enzymology — Pancreatitis/chemically induced/complications/metabolism — Receptors, Cell Surface/metabolism — Toll-Like Receptor 4 — Toll-Like Receptors
Identifiers		PMID: 15286555
Full text		Article (Published version) (880 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		Mucoviscidose et jonctions GAP (229) Pharmacologie et imagerie du foie (664) Physiopathologie de la pancréatite aiguë (601)
Citation (ISO format)		PASTOR, Catherine et al. Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. In: Critical Care Medicine, 2004, vol. 32, n° 8, p. 1759-63. https://archive-ouverte.unige.ch/unige:27046