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Title

Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia
Authors
Pastor, Catherine
Pugin, Jérôme
Kwak, Brenda
Chanson, Marc
Mach, François
Hadengue, Antoine
Frossard, Jean-Louis
Published in Critical Care Medicine. 2004, vol. 32, no. 8, p. 1759-63
Abstract Infection of pancreatic necrosis is a severe complication of acute pancreatitis. Because Toll-like receptor 4 (TLR4) has been identified as a receptor necessary to transduct the signal of bacteria-derived lipopolysaccharide into cells, we investigated the role of TLR4 on pancreatic and pulmonary injury in acute pancreatitis and acute pancreatitis associated with endotoxemia in wild-type and TLR4-deficient mice.
Keywords Acute Disease — Amylases/blood/secretion — Animals — Caerulein — Disease Models, Animal — Lipopolysaccharides — Lung Diseases/chemically induced/etiology/metabolism — Membrane Glycoproteins/metabolism — Mice — Pancreas/enzymology — Pancreatitis/chemically induced/complications/metabolism — Receptors, Cell Surface/metabolism — Toll-Like Receptor 4 — Toll-Like Receptors
Identifiers
PMID: 15286555
Full text
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Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups Physiopathologie de la pancréatite aiguë (601)
Pharmacologie et imagerie du foie (664)
Mucoviscidose et jonctions GAP (229)
Citation
(ISO format) 		PASTOR, Catherine et al. Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. In: Critical Care Medicine, 2004, vol. 32, n° 8, p. 1759-63. https://archive-ouverte.unige.ch/unige:27046

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Deposited on : 2013-03-26

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