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Scientific article
English

Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia

Published inCritical care medicine, vol. 32, no. 8, p. 1759-1763
Publication date2004
Abstract

Infection of pancreatic necrosis is a severe complication of acute pancreatitis. Because Toll-like receptor 4 (TLR4) has been identified as a receptor necessary to transduct the signal of bacteria-derived lipopolysaccharide into cells, we investigated the role of TLR4 on pancreatic and pulmonary injury in acute pancreatitis and acute pancreatitis associated with endotoxemia in wild-type and TLR4-deficient mice.

Keywords
  • Acute Disease
  • Amylases/blood/secretion
  • Animals
  • Caerulein
  • Disease Models, Animal
  • Lipopolysaccharides
  • Lung Diseases/chemically induced/etiology/metabolism
  • Membrane Glycoproteins/metabolism
  • Mice
  • Pancreas/enzymology
  • Pancreatitis/chemically induced/complications/metabolism
  • Receptors, Cell Surface/metabolism
  • Toll-Like Receptor 4
  • Toll-Like Receptors
Citation (ISO format)
PASTOR, Catherine et al. Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. In: Critical care medicine, 2004, vol. 32, n° 8, p. 1759–1763.
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Article (Published version)
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Identifiers
ISSN of the journal0090-3493
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