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Title

Interactions of connexins with other membrane channels and transporters

Authors
Kotsias, Basilio A
Peracchia, Camillo
O'Grady, Scott M
Published in Progress in Biophysics & Molecular Biology. 2007, vol. 94, no. 1-2, p. 233-44
Abstract Cell-to-cell communication through gap junctions exists in most animal cells and is essential for many important biological processes including rapid transmission of electric signals to coordinate contraction of cardiac and smooth muscle, the intercellular propagation of Ca(2+) waves and synchronization of physiological processes between adjacent cells within a tissue. Recent studies have shown that connexins (Cx) can have either direct or indirect interactions with other plasma membrane ion channels or membrane transport proteins with important functional consequences. For example, in tissues most severely affected by cystic fibrosis (CF), activation of the CF Transmembrane Conductance Regulator (CFTR) has been shown to influence connexin function. Moreover, a direct interaction between Cx45.6 and the Major Intrinsic Protein/AQP0 in lens appears to influence the process of cell differentiation whereas interactions between aquaporin 4 (AQP4) and Cx43 in mouse astrocytes may coordinate the intercellular movement of ions and water between astrocytes. In this review, we discuss evidence supporting interactions between Cx and membrane channels/transporters including CFTR, aquaporins, ionotropic glutamate receptors, and between pannexin1, another class of putative gap-junction-forming proteins, and Kvbeta3, a regulatory beta-subunit of voltage gated potassium channels. Although the precise molecular nature of these interactions has yet to be defined, their consequences may be critical for normal tissue homeostasis.
Keywords Biological Transport, Active/physiologyCell Communication/physiologyConnexins/metabolismGap Junctions/metabolismIon Channels/metabolismMembrane Transport Proteins/metabolismModels, BiologicalProtein Binding
Identifiers
PMID: 17475311
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Structures
Research group Mucoviscidose et jonctions GAP (229)
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(ISO format)
CHANSON, Marc et al. Interactions of connexins with other membrane channels and transporters. In: Progress in Biophysics & Molecular Biology, 2007, vol. 94, n° 1-2, p. 233-44. doi: 10.1016/j.pbiomolbio.2007.03.002 https://archive-ouverte.unige.ch/unige:27036

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Deposited on : 2013-03-26

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