UNIGE document Scientific Article
previous document  unige:26963  next document
add to browser collection
Title

GABA neurons of the VTA drive conditioned place aversion

Authors
Mirzabekov, Julie J
Doehner, Jana
Deisseroth, Karl
Tye, Kay M
show hidden authors show all authors [1 - 9]
Published in Neuron. 2012, vol. 73, no. 6, p. 1173-83
Abstract Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
Keywords Action Potentials/drug effects/geneticsAnalgesics, Opioid/pharmacologyAnalysis of VarianceAnimalsApomorphine/pharmacologyBacterial Proteins/genetics/metabolismConditioning, Operant/drug effects/physiologyDopamine Agonists/pharmacologyDopamine Antagonists/pharmacologyDopaminergic Neurons/drug effects/physiologyElectroshock/adverse effectsEscape Reaction/drug effects/physiologyG Protein-Coupled Inwardly-Rectifying Potassium Channels/deficiency/geneticsGABAergic Neurons/drug effects/physiologyGlutamate Decarboxylase/geneticsHaloperidol/pharmacologyLuminescent Proteins/genetics/metabolismMiceMice, Inbred C57BLMice, TransgenicMorphine/pharmacologyOptics and PhotonicsRhodopsin/genetics/metabolismTime FactorsTyrosine 3-Monooxygenase/genetics/metabolismVentral Tegmental Area/cytology/drug effects
Identifiers
PMID: 22445344
Full text
Article (Published version) (1.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
Citation
(ISO format)
TAN, Kelly et al. GABA neurons of the VTA drive conditioned place aversion. In: Neuron, 2012, vol. 73, n° 6, p. 1173-83. https://archive-ouverte.unige.ch/unige:26963

187 hits

1 download

Update

Deposited on : 2013-03-25

Export document
Format :
Citation style :