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NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD)

Malenka, Robert C
Published in Cold Spring Harbor Perspectives in Biology. 2012, vol. 4, no. 6
Abstract Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-d-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre- and postsynaptic neurons. The early phases of expression are mediated by a redistribution of AMPA-type glutamate receptors: More receptors are added to potentiate the synapse or receptors are removed to weaken synapses. With time, structural changes become apparent, which in general require the synthesis of new proteins. The investigation of the molecular and cellular mechanisms underlying these forms of synaptic plasticity has received much attention, because NMDA receptor-dependent LTP and LTD may constitute cellular substrates of learning and memory.
Keywords HumansLearningLong-Term Potentiation/physiologyLong-Term Synaptic Depression/physiologyMemoryReceptors, N-Methyl-D-Aspartate/physiologySignal Transduction
PMID: 22510460
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Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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LUESCHER, Christian, MALENKA, Robert C. NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). In: Cold Spring Harbor Perspectives in Biology, 2012, vol. 4, n° 6. doi: 10.1101/cshperspect.a005710 https://archive-ouverte.unige.ch/unige:26961

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Deposited on : 2013-03-25

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