Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour
ContributorsPascoli, Vincent Jean; Turiault, Marc; Luescher, Christian
Published inNature, vol. 481, no. 7379, p. 71-75
Publication date2012
Abstract
Keywords
- Adaptation, Physiological/drug effects
- Animals
- Cocaine/administration & dosage/pharmacology
- Cocaine-Related Disorders/metabolism/pathology
- Dopaminergic Neurons/drug effects/metabolism
- Electric Stimulation
- Enzyme Activation
- Excitatory Postsynaptic Potentials/drug effects
- Extracellular Signal-Regulated MAP Kinases/metabolism
- Injections
- Long-Term Potentiation/drug effects
- MAP Kinase Signaling System/drug effects
- Mice
- Mice, Inbred C57BL
- Motor Activity/drug effects
- Neuronal Plasticity/drug effects
- Nucleus Accumbens/cytology/drug effects
- Phenotype
- Receptors, Dopamine D1/metabolism
- Synapses/drug effects/metabolism
- Synaptic Transmission/drug effects
Funding
- Swiss National Science Foundation - NCCR SYNAPSY - The Synaptic Bases of Mental Diseases
Citation (ISO format)
PASCOLI, Vincent Jean, TURIAULT, Marc, LUESCHER, Christian. Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. In: Nature, 2012, vol. 481, n° 7379, p. 71–75. doi: 10.1038/nature10709
Main files (2)
Article (Published version)
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Article (Accepted version)
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Secondary files (1)
Identifiers
- PID : unige:26937
- DOI : 10.1038/nature10709
- PMID : 22158102
ISSN of the journal0028-0836