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Title

Is there a way to curb benzodiazepine addiction?

Authors
Rudolph, Uwe
Published in Swiss Medical Weekly. 2011, vol. 141, p. w13277
Abstract Benzodiazepines are widely prescribed drugs used to treat anxiety and insomnia, induce muscle relaxation, control epileptic seizures, promote anaesthesia or produce amnesia. Benzodiazepines are also abused for recreational purposes and the number of benzodiazepine abusers is unfortunately increasing. Within weeks of chronic use, tolerance to the pharmacological effects can develop and withdrawal becomes apparent once the drug is no longer available, which are both conditions indicative of benzodiazepine dependence. Diagnosis of addiction (i.e. compulsive use despite negative consequences) may follow in vulnerable individuals. Here, we review the historical and current use of benzodiazepines from their original synthesis, discovery and commercialisation to the recent identification of the molecular mechanism by which benzodiazepines induce addiction. These results have identified the mechanisms underlying the activation of midbrain dopamine neurons by benzodiazepines, and how these drugs can hijack the mesocorticolimbic reward system. Such knowledge calls for future developments of new receptor subtype specific benzodiazepines with a reduced addiction liability.
Keywords Benzodiazepines/history/pharmacologyDopaminergic Neurons/drug effectsHistory, 20th CenturyHumansMesencephalon/drug effectsSubstance-Related Disorders/genetics/prevention & control
Identifiers
PMID: 22012428
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Article (Published version) (343 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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(ISO format)
LALIVE D'EPINAY, Arnaud et al. Is there a way to curb benzodiazepine addiction?. In: Swiss Medical Weekly, 2011, vol. 141, p. w13277. https://archive-ouverte.unige.ch/unige:26936

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Deposited on : 2013-03-25

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