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Hooked on benzodiazepines: GABAA receptor subtypes and addiction

Rudolph, Uwe
Published in Trends in Neurosciences. 2011, vol. 34, no. 4, p. 188-97
Abstract Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover, benzodiazepines are often abused after chronic clinical treatment and also for recreational purposes. Within weeks, tolerance to the pharmacological effects can develop as a sign of dependence. In vulnerable individuals with compulsive drug use, addiction will be diagnosed. Here we review recent observations from animal models regarding the cellular and molecular basis that might underlie the addictive properties of benzodiazepines. These data reveal how benzodiazepines, acting through specific GABA(A) receptor subtypes, activate midbrain dopamine neurons, and how this could hijack the mesolimbic reward system. Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability.
Keywords AnimalsAnxiety Disorders/drug therapyBehavior, AddictiveBenzodiazepines/adverse effects/metabolism/therapeutic useDopamine/metabolismGABA Modulators/adverse effects/metabolism/therapeutic useHumansNeurons/metabolismProtein Subunits/metabolismReceptors, GABA-A/metabolismRewardSubstance-Related Disorders/physiopathologyVentral Tegmental Area/metabolism
PMID: 21353710
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Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
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TAN, Kelly, RUDOLPH, Uwe, LUESCHER, Christian. Hooked on benzodiazepines: GABAA receptor subtypes and addiction. In: Trends in Neurosciences, 2011, vol. 34, n° 4, p. 188-97. https://archive-ouverte.unige.ch/unige:26928

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Deposited on : 2013-03-25

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